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Detection and co-occurrence of Acanthamoeba and Klebsiella pneumoniae in freshwater river systems of Taichung, Taiwan.
BMC Microbiol
March 2025
Department of Parasitology, School of Medicine, China Medical University, Taichung, Taiwan.
Background: This study focuses on the detection and co-occurrence of Acanthamoeba and Klebsiella pneumoniae in freshwater river systems. Both microorganisms are known for their pathogenic potential, with Acanthamoeba capable of causing infections such as amoebic keratitis, and K. pneumoniae being a common cause of community infections.
View Article and Find Full Text PDFA Clinicoradiological and Bacteriological Profile of Community-acquired Pneumonia in a Tertiary Care Center in Eastern India.
J Assoc Physicians India
March 2025
Professor, Department of Chest Medicine, IQ City Medical College Hospital, Durgapur, West Bengal, India.
Introduction: The world of microbes as a causative agent of community-acquired pneumonia (CAP) has been ever-changing with the emergence of new species, introduction of newer diagnostic techniques, availability of newer antibiotics and vaccines, and changing demographic profiles of patients as reported from different parts of the globe over time.
Objective: The aim of the present study is to evaluate the clinicoradiological and bacteriological profile of CAP among patients admitted to a tertiary care hospital with special reference to the CURB-65 score and acute inflammatory markers.
Materials And Methods: It was a descriptive, observational, cross-sectional study conducted over a period of 18 months in the Department of Respiratory Medicine in a tertiary care hospital in the Indian subcontinent.
Antimicrobial-Resistant Infections in Hospitalized Patients.
JAMA Netw Open
March 2025
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia.
Importance: Antimicrobial resistance is a major public health problem in the US. Estimating national rates of antimicrobial-resistant infections commonly associated with health care can aid in targeted public health efforts.
Objective: To determine the national incidence rates of 6 pathogens over time: methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus spp (VRE), extended-spectrum cephalosporin-resistant Escherichia coli and Klebsiella spp (excluding Klebsiella aerogenes) (ESCR-EK), carbapenem-resistant Enterobacterales (CRE), carbapenem-resistant Acinetobacter spp (CRAsp), and multidrug-resistant (MDR) Pseudomonas aeruginosa.
A guide to empirical management of urinary tract infection in outpatient setting in a tertiary care institute: A study from Western India.
J Postgrad Med
March 2025
Department of Microbiology, Mahatma Gandhi Medical University of Medical Sciences and Technology Jaipur, Rajasthan, India.
Introduction: Urinary tract infections make up a major proportion of infections encountered in outpatient setting in hospitals. Treatment is largely based on the epidemiology of locally prevalent flora. Selection of an appropriate antibiotic is crucial, as inappropriate use could contribute to an alarming rise in antimicrobial resistance.
View Article and Find Full Text PDFImpact of tebipenem pivoxil on the intestinal microbiota and on establishment of colonization with carbapenem-resistant in mice.
Microbiol Spectr
March 2025
Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Tebipenem pivoxil has potent activity against pathogens, but requires combination with β-lactamase inhibitor to achieve activity against carbapenemase producers, including metallo-β-lactamases (MBLs). Herein, we evaluate the potential of tebipenem pivoxil, alone and in combination with the prodrug of the experimental MBL inhibitor CS319 (CS319-piv-SAc), to disrupt the indigenous mice microbiota of the colon and promote colonization by pathogens. The effect of antibiotic treatment (daily for 3 days with subcutaneous saline [control], subcutaneous clindamycin, oral tebipenem pivoxil alone and in combination with CS319-piv-Sac, or oral CS319-piv-Sac) on the intestinal microbiota was assessed by culture for enterococci and facultative Gram-negative bacilli and by 16S rRNA amplicon sequencing.
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