The aim of this study was to review the United Kingdom Children's Cancer Study Group (UKCCSG) experience of sacrococcygeal teratomas (SCT) including histological presentation, response to surgery and chemotherapy, and long term effects of the tumour and treatment. This paper presents the results for those children diagnosed during the neonatal period. Children aged up to 4 weeks with biopsy proven localised or metastatic sacrococcygeal germ cell tumours were eligible. From 1st January 1989 to 31st December 1997 (9 years), 15 UKCCSG centres registered 51 neonates with SCT into GC 8901. Surgery alone was performed in all and the prognosis was good - except for 1 baby who died from massive haemorrhage at the initial operation and 1 who died from the complications of prematurity. Seven of the 51 children (14%) who had teratomas in the neonatal period (5 mature, two immature) had yolk sac tumour (YST) recurrence at: 4, 12, 15, 20, 20, 28 and 32 months of age. These children received chemotherapy in the form of etoposide/bleomycin/carboplatin (JEB) and are alive and well at review. These results emphasise the need for oncological follow-up of SCT and the good response to JEB chemotherapy of malignant teratomas and YST.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00383-002-0884-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Proposal of a novel index in assessing perinatal mortality in prenatal diagnosis of Sacrococcygeal Teratoma.
J Perinat Med
January 2025
Fetal Medicine Unit, Grupo CERAS, Clinica Anglo Americana, British Medical Hospital, Lima, Peru.
Objectives: To describe obstetric characteristics and perinatal outcomes in a serie of fetuses with Sacrococcygeal Teratoma (SCT) and propose a novel index to assess postnatal mortality based on the THC ratio and the addition of the presence of polyhydramnios.
Methods: A retrospective study in a referral teaching hospital between 2013 and 2023. A descriptive analysis and a receiver operating characteristic (ROC) curve were performed to the determine the optimal cutoff value of the THC plus polyhydramnios based on optimal sensitivity and specificity.
Fœtal sacrococcygeal teratoma type I: A case report.
Radiol Case Rep
February 2025
Pediatric Surgery Department, Tunis Faculty of Medicine El Manar University, Béchir Hamza Children's Hospital, Tunis, Tunisia.
Sacrococcygeal teratoma (SCT) is a rare congenital tumor typically diagnosed in neonates, with management challenges arising from the size of the tumor and associated delivery complications. In this case, a 32-year-old gravida 5 para 5 woman with a history of three prior cesarean sections was diagnosed with a giant type I SCT at 30 weeks of gestation through prenatal ultrasound, confirmed by fetal MRI. At 34 weeks, an emergency cesarean section was performed due to acute fetal distress, resulting in a newborn with transient respiratory distress.
View Article and Find Full Text PDFSacrococcygeal Teratoma With a Unique Gastrointestinal Presentation of Necrotizing Enterocolitis.
Cureus
November 2024
Department of Radiology, All India Institute of Medical Sciences, Patna, Patna, IND.
Article Synopsis
- A neonate with a mass in the coccygeal area experienced severe abdominal issues on day 4, including distension and bloody stomach contents, leading to a diagnosis of necrotizing enterocolitis.
- Imaging indicated the coccygeal mass was a Type II sacrococcygeal teratoma, which likely caused bowel compression and contributed to the gut's digestive issues.
- After the mass was surgically removed, the neonate showed no further symptoms, highlighting the need for careful observation in similar cases to catch potential complications early.
Mediastinal Teratoma with Nephroblastomatous Elements: Case Report, Literature Review, and Comparison with Maturing Fetal Glomerulogenic Zone/Definitive Zone Ratio and Nephrogenic Rests.
Int J Mol Sci
November 2024
Department of Pathology, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON K1H 8L1, Canada.
Article Synopsis
- Extrarenal teratoid Wilms' tumor (TWT) is a rare type of cancer with complex histology, making diagnosis challenging; the case discussed involves an 8-year-old girl with a mediastinal mass containing nephroblastomatous elements.
- Surgical resection revealed a mature cystic teratoma mixed with nephroblastoma, and immunohistochemical tests confirmed the diagnosis, leading to a smooth recovery for the patient.
- This case emphasizes the importance of detailed histopathological analysis in distinguishing TWT from other tumors, underlining the necessity for long-term monitoring due to potential recurrence.
An atypical abdominal manifestation of retroperitoneal teratoma: Case report.
Int J Surg Case Rep
December 2024
Department of Pediatric Surgery I, The University of Child Health Sciences and The Children's Hospital, Lahore, Pakistan.
Introduction & Importance: Teratomas, typically situated in midline areas like the sacrococcygeal region, may rarely manifest in the retroperitoneal region. Often asymptomatic and incidentally discovered, they can lead to complications such as infection, tumor rupture, or, exceptionally, peritonitis.
Case Presentation: In a 2-year-old child with a history of trauma, an atypical presentation of acute abdomen and peritonitis was observed.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!