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Comparison of the effect of NT-0409 and antidementia drugs on learning and memory in rats with chronic cerebral cholinergic deficiency. | LitMetric
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Comparison of the effect of NT-0409 and antidementia drugs on learning and memory in rats with chronic cerebral cholinergic deficiency.

N N Lermontova T V Mukhina G I Van'kin T P Serkova S O Bachurin

Bull Exp Biol Med

Laboratory of Neurochemistry, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka.

Published: January 2003

Systemic oral administration of NT-0409, a new synthetic agonist of AMPA subtype glutamate receptor, to rats with chronic partial AF64A-induced deprivation of cholinergic functions improved their learning in a Morris water maze. NT-0409 is close to memantine by the effect on learning and, in contrast to cholinomimetic arisept, ensures longer retention of the developed habit.

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http://dx.doi.org/10.1023/a:1023493828612DOI Listing

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