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Necrolytic migratory erythema: a fortuitous diagnosis.
BMJ Case Rep
November 2024
Dermatology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.
A woman in her late 60s presented with widespread, itchy, dark lesions over her trunk and legs for 1 month. Initially, she was managed as nutritional dermatitis and experienced partial improvement. However, her condition worsened over 2 months, characterised by aggravated skin lesions, new-onset diabetes and a 12 kg weight loss.
View Article and Find Full Text PDFSkin as a Reflection of Gut Health: An Overview of Dermatological Manifestations in Primary Neoplastic and Autoimmune Gastrointestinal Disorders.
Cureus
October 2024
Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, PAK.
Gastrointestinal (GI) diseases can present with several extraintestinal manifestations, and cutaneous signs and symptoms are most frequent. Although conventionally GI and skin are considered two entirely separate organ systems, they are closely correlated in origin. An increasing amount of data highlights the complex relationship between GI and dermatological conditions.
View Article and Find Full Text PDFGlucagon-Producing Pancreatic Neuroendocrine Tumors (Glucagonomas) are Enriched in Aggressive Neoplasms with ARX and PDX1 Co-expression, DAXX/ATRX Mutations, and ALT (Alternative Lengthening of Telomeres).
Endocr Pathol
December 2024
Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Piazzale L.A. Scuro, 10, 37134, Verona, Italy.
Article Synopsis
- Glucagonomas are special tumors in the pancreas that cause a syndrome and were studied in six patients to understand their features better.
- These tumors were mostly large and showed a common skin symptom called necrolytic migratory erythema in all patients.
- The tumors had specific changes in their genes and were linked to serious aggressive behavior, which means they can spread or grow badly in some patients.
Manifestations of Endocrine Disease in the Lower Extremities: Beyond the Diabetic Foot.
Int J Low Extrem Wounds
September 2024
Diabetes Centre, Second Department of Internal Medicine, University Hospital of Alexandroupolis, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
Article Synopsis
- The review discusses various endocrine diseases and their effects on the lower extremities, excluding diabetic foot.
- Conditions such as acromegaly, Addison's disease, and thyroid disorders can manifest with distinct clinical signs in this area.
- Early diagnosis through clinical suspicion and treating the endocrine issue typically leads to improvement in symptoms related to the lower extremities.
A nuclear beacon of hope: an advanced, metastatic glucagonoma treated with [177Lu]Lu-DOTA-TATE.
Nucl Med Rev Cent East Eur
September 2024
Department of Endocrinology and Radioisotope Therapy, Military Institute of Medicine - National Research Institute, Warsaw, Poland.
Article Synopsis
- Glucagonoma is a rare type of pancreatic tumor that leads to overproduction of glucagon and is associated with symptoms like necrolytic migratory erythema.
- First-line treatments include surgery and somatostatin analogs, while radioligand therapy with [177Lu]Lu-DOTA-TATE is used as a second-line option for advanced cases.
- This text discusses a unique case of a metastatic glucagonoma successfully treated with [177Lu]Lu-DOTA-TATE when the disease progressed.
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