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Vulvodynia - A contemporary understanding and practical approach in primary care settings.
Malays Fam Physician
December 2024
MCGP, FRCOG, Department of Obstetrics and Gynaecology, IMU University, Clinical Campus, Jalan Rasah, Bukit Rasah, Seremban, Negeri Sembilan, Malaysia.
Vulvodynia manifests as persistent vulvar pain, affecting both sexual well-being and overall quality of life. While the precise cause remains elusive, various multifaceted predisposing and precipitating factors have been identified. Neurobiological and psychosocial elements contribute to a better understanding of the management of this complex disorder.
View Article and Find Full Text PDFIntraoperative Pain Management for Treatment-Resistant Complex Regional Pain Syndrome: A Case Report.
Cureus
November 2024
Anesthesiology, Jackson Memorial Hospital, Miami, USA.
Complex regional pain syndrome (CRPS) is a chronic neuropathic pain disorder often following trauma, associated with severe pain and autonomic disturbances in the affected limbs. Managing CRPS is challenging due to the lack of FDA-approved medications, often requiring off-label treatments. Traditional options like nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids show limited efficacy, while adjunctive treatments such as gabapentin, antidepressants, and bisphosphonates are increasingly favored.
View Article and Find Full Text PDFChronic low back pain is a prevalent and debilitating condition that often resists traditional management strategies such as physical therapy, pharmacotherapy, and interventional procedures. The erector spinae plane (ESP) block, a relatively new regional anesthesia technique, has shown promise in managing various types of pain, including chronic conditions. This case report details the use of the ESP block in a male patient in his late 60's with chronic low back pain unresponsive to conventional treatments, including acetaminophen, muscle relaxants, gabapentin, epidural steroid injections, diagnostic medial branch blocks, and sacroiliac joint injections.
View Article and Find Full Text PDFThe Role of Pain Medications in Modulating Peripheral Nerve Injury Recovery.
J Clin Pharmacol
November 2024
Department of Chemistry and Physics, Southern Utah University, Cedar City, UT, USA.
Peripheral nerve injuries (PNIs) are common, costly, and cause significant pain. Effective management of PNIs involves tailoring medications to the injury type as well as understanding the pharmacokinetics/pharmacodynamics to support nerve regeneration and reduce pain. Opioids act on opioid receptors to significantly reduce pain for many patients, but there are significant addiction risks and side effects.
View Article and Find Full Text PDFEnhancing analgesia in acute renal colic pain: a randomized controlled trial of gabapentin adjunct to ketorolac-based regimen.
Front Pain Res (Lausanne)
October 2024
Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Background: Renal colic is characterized by severe pain that is highly disabling. Gabapentin, an antiepileptic medication, is often recommended as a first-line therapy for neuropathic pain. However, its effectiveness in managing somatic pain, which is defined as the result of activity by pain receptors in the deep tissues, such as renal colic pain, is not as well-established.
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