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Article Synopsis
  • - Parinaud oculoglandular syndrome (POGS) is a rare condition characterized by one-sided eye inflammation and lymph node swelling, often linked to cat scratch disease (CSD) caused by Bartonella henselae (BH).
  • - Diagnosing POGS can be difficult due to its rarity and the wide range of potential causes, with the best diagnostic method being the PCR DNA test for BH, which isn't always readily available.
  • - A series of three cases demonstrated effective management with antibiotics and non-drug measures like flea control, stressing the need for increased awareness among clinicians regarding CSD, especially in patients with feline exposure, and calling for more research to improve diagnosis and treatment options.
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Queuosine salvage in Houston 1: a unique evolutionary path.

Microbiology (Reading)

September 2024

Department of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611, USA.

Queuosine (Q) stands out as the sole tRNA modification that can be synthesized via salvage pathways. Comparative genomic analyses identified specific bacteria that showed a discrepancy between the projected Q salvage route and the predicted substrate specificities of the two identified salvage proteins: (1) the distinctive enzyme tRNA guanine-34 transglycosylase (bacterial TGT, or bTGT), responsible for inserting precursor bases into target tRNAs; and (2) queuosine precursor transporter (QPTR), a transporter protein that imports Q precursors. Organisms such as the facultative intracellular pathogen , which possess only bTGT and QPTR but lack predicted enzymes for converting preQ to Q, would be expected to salvage the queuine (q) base, mirroring the scenario for the obligate intracellular pathogen .

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Article Synopsis
  • A 13-year-old healthy boy presented with a persistent right neck mass, fatigue, and weight loss, raising concerns about potential cancer.
  • After initial tests showed no abnormalities, he returned with new symptoms like swallowing difficulties and throat pain, and the neck mass had changed appearance.
  • Blood tests indicated infection, leading to a diagnosis of lymphoid proliferation and treatment with antibiotics, resulting in significant symptom improvement and near resolution of the mass.
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Purpose: To investigate the value of metagenomic next-generation sequencing (mNGS) for virus detection in patients with suspected viral infectious uveitis.

Methods: In this retrospective, multicenter case series study, 70 patients with suspected viral infectious uveitis were recruited. All patients underwent mNGS test using intraocular fluid samples and serological screening tests for pathogens.

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Unusual presentation of cat scratch disease: case report.

Eur J Clin Microbiol Infect Dis

August 2024

Department of Pediatrics, Division of Pediatric Infectious Diseases, Faculty of Medicine, Marmara University, Fevzi Cakmak, Muhsin Yazicioglu St, No:10, Floor: 6, Istanbul, Turkey.

Cat scratch disease (CSD) is an infection caused by Bartonella henselae, presents with non-specific symptoms like lymphadenopathy, fever, and fatigue. It can progress to disseminated disease, leading to complications such as liver and splenic micro abscesses, osteomyelitis, encephalitis, and uveitis. Diagnosis is challenging due to varied presentations and limited tests.

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