AI Article Synopsis
- Amyloidosis is a serious disease that can affect the heart, and this study looked at patients with significant cardiac involvement resulting in heart failure from 1997 to 2000.
- Eight patients were identified, all presenting with heart failure, and despite advanced medical treatment, seven of the eight patients died within a year due to severe heart complications.
- The study highlighted that acquired cardiac amyloidosis has a poor prognosis because patients often arrive at diagnosis in an advanced stage of the disease, with only one patient surviving after a liver transplant for hereditary amyloidosis.
Article Abstract
Objective: Amyloidosis is a systemic disease potentially afflicting the heart. In this study we retrospectively studied patients presenting with major cardiac amyloidotic involvement.
Methods And Results: From 1997 until 2000, eight patients with major cardiac involvement of amyloidosis resulting in heart failure were diagnosed. All patients presented with heart failure. Diagnostic work-up, clinical, electrocardiographic, echocardiographic characteristics and treatment modalities are presented. Seven patients with acquired (both primary AL and postinflammatory AA) amyloidosis out of a total of eight patients died within one year after diagnosis, as a result of intractable cardiac failure due to both systolic and diastolic left ventricular dysfunction despite state-of-the-art medical treatment of heart failure. Only one patient with hereditary amyloidosis undergoing liver transplantation survived.
Conclusions: Despite optimal medical cardiac failure treatment, acquired cardiac amyloidosis carries an ominous prognosis probably because patients are already in a very advanced stage of the disease at presentation.
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| http://dx.doi.org/10.2143/AC.58.2.2005267 | DOI Listing |
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