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Precision Treatment of Metachronous Multiple Primary Malignancies Based on Constructing Patient Tumor-Derived Organoids.
Biomedicines
November 2024
Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.
When a patient has two or more primary tumors, excluding the possibility of diffuse, recurrent, or metastatic, they can be defined as having multiple primary malignant neoplasms (MPMNs). Moreover, cases of three primary urinary tract tumors are very rare. Here, we reported a patient of MPMNs with four primary tumors, including three urinary tract cancers (renal cancer, prostate cancer, and bladder cancer) and lung cancer.
View Article and Find Full Text PDFObstetric Outcomes by Hospital Volume of Operative Vaginal Delivery.
JAMA Netw Open
January 2025
Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland.
Article Synopsis
- This study examined how the volume of operative vaginal deliveries (OVDs) at hospitals in California from 2008 to 2020 affects adverse outcomes for both birthing individuals and newborns.
- It categorized hospital OVD volume into low (less than 5.2%), medium (5.2%-7.4%), and high (7.4% or more), finding that lower volume hospitals had a higher incidence of complications such as obstetric anal sphincter injuries and adverse neonatal outcomes.
- The research utilized extensive data from birth certificates and hospital records to analyze trends, highlighting the need for improvements in obstetric care based on hospital performance.
Perspective: Incidence of Clinician-Diagnosed Lyme Disease in Manitoba, Canada 2009-2018.
Vector Borne Zoonotic Dis
January 2025
Infectious Diseases and Vaccine Programs Branch, Public Health Agency of Canada, Saint-Hyacinthe, Canada.
Article Synopsis
- Lyme disease (LD) surveillance in Manitoba faces challenges, including underreporting, which affects the understanding of disease trends and distribution.
- A retrospective analysis from 2009 to 2018 identified 1,658 clinician-diagnosed LD cases from over 1.6 million registrants, with the majority occurring during peak tick activity (May to July).
- Annualized findings revealed a mean incidence of 10.17 cases per 100,000 people, significantly higher than the 30 cases reported by the Manitoba Health surveillance system, highlighting the extent of underreporting.
Incarceration is associated with higher mortality after trauma: An unreported health care disparity.
J Trauma Acute Care Surg
January 2025
From the Division of Plastic and Reconstructive Surgery, Department of Surgery (H.N.-P.), Albany Medical Center, Albany, New York; Johns Hopkins Bloomberg School of Public Health (H.N.-P., E.R.H.); Division of Acute Care Surgery, Department of Surgery (J.P.B., E.R.H.), Johns Hopkins Medicine, Baltimore, Maryland; Division of General Surgery, Department of Surgery (J.P.B.), University of British Columbia, Vancouver, British Columbia, Canada; and Department of Plastic and Reconstructive Surgery (C.S.H.), WakeMed Health and Hospitals, Raleigh, North Carolina.
Background: While the United States has the highest incarceration rate worldwide, at nearly 1% of the adult population (more than 2 million people), insights regarding health disparities in this population remain limited. This retrospective cohort study represents the largest national database analysis of incarcerated trauma patients to date and investigates whether incarceration status is an independent risk factor for poor outcomes after trauma for US adults.
Methods: We analyzed data from the National Trauma Data Bank from 2017 to 2018.
A Case of Thermal Burns of the Larynx in a Toddler.
Cureus
December 2024
Otolaryngology, Head and Neck Surgery, Ehime University Graduate School of Medicine, Toon, JPN.
Thermal burns of the larynx are uncommon but can lead to serious upper airway obstruction due to edema and bleeding, especially in children who may struggle to communicate their symptoms effectively. This report presents the case of a one-year-and-seven-month-old boy who developed stridor and respiratory distress after eating a heated potato, which ultimately required tracheal intubation. The initial evaluation suggested foreign body aspiration; however, laryngoscopy confirmed significant arytenoid swelling and airway narrowing due to thermal burns.
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