A transformation factor is described which related in vitro drug dissolution from a preparation to the corresponding in vivo plasma drug concentrations. This factor, derived from the dissolution profile and the corresponding in vivo plasma concentration of a single formulation, was used to predict plasma concentration profiles of similar formulations simply from dissolution data.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/jps.2600650432 | DOI Listing |
Publication Analysis
Top Keywords
plasma drug
8
corresponding vivo
8
vivo plasma
8
plasma concentration
8
simple transformation
4
transformation method
4
method predicting
4
plasma
4
predicting plasma
4
drug profiles
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!