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Formulation Factors Affecting the Formation of Visible-Bubbles During the Reconstitution Process of Freeze-Dried Etanercept Formulations: Protein Concentration, Stabilizers, and Surfactants.
AAPS J
January 2025
Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Freeze drying is one of the common methods to extend the long-term stability of biologicals. Biological products in solid form have the advantages of convenient transportation and stable long-term storage. However, long reconstitution time and extensive visible bubbles are frequently generated during the reconstitution process for many freeze-dried protein formulations, which can potentially affect the management efficiency of staff, patient compliance, and product quality.
View Article and Find Full Text PDFFructose-Driven glycolysis supports synaptic function in subterranean rodent - Gansu Zokor (Eospalax cansus).
Neuroscience
January 2025
Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, China; National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, China; College of Life Science, Shaanxi Normal University, Xi'an, China. Electronic address:
Several studies indicate that fructose can be used as an energy source for subterranean rodents. However, how subterranean rodents utilize fructose metabolism with no apparent physiological drawbacks remains poorly understood. In the present study, we measured field excitatory postsynaptic potentials (fEPSPs) in hippocampal slices from Gansu zokor and SD rats hippocampi before and 60 min after replacement of 10 mM glucose in the artificial cerebrospinal fluid (ACSF) with 10 mM fructose (gassed with 95 % O and 5 % CO).
View Article and Find Full Text PDFVisualising Analytes in Gas Chromatography by Staining and Substance Maps.
Talanta
January 2025
Institute of Chemistry of Renewable Resources, Department of Chemistry, BOKU University, Konrad-Lorenz-Straße 24, 3430, Tulln, Austria. Electronic address:
Chromatographic separations in combination with spectroscopic detectors are a main pillar of today's analytical chemistry. The recorded spectroscopic data is usually not shown in a typical chromatogram, therefore the contained additional information cannot be accessed readily by the analyst and is inspected in tedious additional routines, such as separate database searches. We developed a method to add colors to gas chromatograms with mass spectral detection.
View Article and Find Full Text PDFPreparation of molecularly imprinted polymer nanoparticles for the extraction and purification of progesterone combined with UPLC-ESI-MS mass spectrometry detection in royal jelly.
J Chromatogr B Analyt Technol Biomed Life Sci
January 2025
Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117 China. Electronic address:
This study aimed to develop molecularly imprinted polymer (MIP) nanoparticles specifically for the selective extraction and enrichment of progesterone (P) from royal jelly (RJ), and quantitatively analyzed them by ultra-performance-liquid chromatography electrospray ionization mass spectrometry (UPLC-ESI-MS). Gaussian software-based theoretical calculations identified methacrylic acid (MAA) as the optimal functional monomer for its strong binding affinity to P. MIP was synthesized by precipitation polymerization, and the preparation process of MIP was optimized by one-way variance design and response surface methodology.
View Article and Find Full Text PDFBiliquid oil-in-water nanofoams and spontaneous emulsification obtained with a surfactant resistant to curvature changes.
J Colloid Interface Sci
January 2025
Institute of Physical and Theoretical Chemistry, University of Regensburg D-93053 Regensburg, Germany. Electronic address:
Hypothesis: Due to its huge polar headgroup, octaoxyethylene octyl ether carboxylic acid (CECHCOOH = Akypo LF2™) is supposed not to be able to change its curvature sufficiently to form bicontinuous microemulsions. Instead, upon adding an oil to the binary water - surfactant system, excess oil could be squeezed out or a biliquid foam could form.
Experiments: An auto-dilution setup was used to record small-angle X-ray scattering data along six dilution lines in the newly established phase diagram of the ternary system 2-ethylhexanol - CECHCOOH - water.
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