The tumors of the brain stem include those of the midbrain, pons, and medulla oblongata. The main purpose of the study was to evaluate the motor system (the motor cortex and pyramidal tract) before and after surgery in patients with brain stem tumors. The study was conducted in 104 patients. In all the patients, motor evoked potentials (MEP) under transcranial magnetic stimulation were recorded before and 2-3 weeks after surgery. Comparing the mean values of MEP indicated a statistically significant decrease in the latent time and the time of central motor conduction, the amplitude of responses being statistically insignificantly changed.

Download full-text PDF

Source

Publication Analysis

Top Keywords

brain stem
12
pyramidal tract
8
patients brain
8
[evaluation pyramidal
4
tract state
4
patients
4
state patients
4
stem tumors]
4
tumors] tumors
4
tumors brain
4

Similar Publications

The substantia nigra pars compacta (SNc), one of the main dopaminergic nuclei of the brain, exerts a regulatory function on the basal ganglia circuitry via the nigro-striatal pathway but its possible dopaminergic innervation of the thalamus has been only investigated in non-human primates. The impossibility of tract-tracing studies in humans has boosted advanced MRI techniques and multi-shell high-angular resolution diffusion MRI (MS-HARDI) has promised to shed more light on the structural connectivity of subcortical structures. Here, we estimated the possible dopaminergic innervation of the human thalamus via an MS-HARDI tractography of the SNc in healthy human young adults.

View Article and Find Full Text PDF

Retinal ganglion cells (RGCs) generally fail to regenerate axons, resulting in irreversible vision loss after optic nerve injury. While many studies have shown that modulating specific genes can enhance RGCs survival and promote optic nerve regeneration, inducing long-distance axon regeneration through single-gene manipulation remains challenging. Nevertheless, combined multi-gene therapies have proven effective in significantly enhancing axonal regeneration.

View Article and Find Full Text PDF

•Defining the concept of "onco-functional" balance.•Detailing the clinical implications in brain tumor surgery.•Discussing the future of this philosophy.

View Article and Find Full Text PDF

Development and maintenance of the nervous system are governed by a scheduled cell death mechanism known as apoptosis. Very much how neurons survive and function depends on the degree of death in differentiating pseudo-neuronal cells produced from neural stem cells. Different inducers can affect the degree of death in these cells: hormones, medicines, growth factors, and others.

View Article and Find Full Text PDF

Sex-determining region Y box 2 (Sox2) is a critical transcription factor for embryogenesis and neural stem and progenitor cell (NSPC) maintenance. While distal enhancers control Sox2 in embryonic stem cells (ESCs), enhancers closer to the gene are implicated in Sox2 transcriptional regulation in neural development. We hypothesize that a downstream enhancer cluster, termed Sox2 regulatory regions 2-18 (SRR2-18), regulates Sox2 transcription in neural stem cells and we investigate this in NSPCs derived from mouse ESCs.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!