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Prader-Willi syndrome protein necdin regulates the nucleocytoplasmic distribution and dopaminergic neuron development.
Sci Rep
December 2024
Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, 410078, Hunan, P. R. China.
Dopamine (DA) plays important roles in various behaviors, including learning and motivation. Recently, THOC5 was identified as an important regulator in the development of dopaminergic neurons. However, how THOC5 is regulated has not been explored.
View Article and Find Full Text PDFFracture strength and marginal and internal adaptation of lithium disilicate and hybrid ceramic endocrowns and non-retentive overlays for endodontically treated molar teeth.
BMC Oral Health
December 2024
Dental Sciences Research Center, Department of Prosthodontics, School of Dentistry, Guilan University of Medical Sciences, Rasht, Iran.
Background: With the advances in the adhesive science, several conservative treatment options such as non-retentive overlays have been suggested for endodontically treated posterior teeth. However, information is scarce regarding the fracture strength and adaptation of non-retentive overlays compared with endocrowns, and the effect of material type in this respect. Thus, this study aimed to assess the fracture strength and internal and marginal adaptation of lithium disilicate (LDS) and hybrid ceramic endocrowns and non-retentive overlays for endodontically treated molar teeth.
View Article and Find Full Text PDFBackstage Heroes-Yeast in COVID-19 Research.
Int J Mol Sci
November 2024
Department of Bioenergetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, 61-614 Poznań, Poland.
The extremely rapid development of understanding and technology that led to the containment of the COVID-19 pandemic resulted from collaborative efforts in the fields of (SARS-CoV-2) biology, pharmacology, vaccinology, and medicine. Perhaps surprisingly, much of the research was conducted using simple and efficient yeast models. In this manuscript, we describe how yeast, eukaryotic microorganisms, have been used to research this global challenge, focusing on the therapeutic potential of the studies discussed herein.
View Article and Find Full Text PDFA modular toolbox for the optogenetic deactivation of transcription.
Nucleic Acids Res
December 2024
Institute of Pharmacy and Molecular Biotechnology (IPMB), Faculty of Engineering Sciences, Heidelberg University, Im Neuenheimer Feld 364, Heidelberg 69120, Germany.
Light-controlled transcriptional activation is a commonly used optogenetic strategy that allows researchers to regulate gene expression with high spatiotemporal precision. The vast majority of existing tools are, however, limited to light-triggered induction of gene expression. Here, we inverted this mode of action and created optogenetic systems capable of efficiently terminating transcriptional activation in response to blue light.
View Article and Find Full Text PDFLessons learned for pandemic preparedness in the neurodegenerative research and clinical fields: an advice report based on Parkinson's disease as an example.
BMC Neurol
December 2024
Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Background: A sustainable pandemic preparedness strategy is essential to ensure equitable access to healthcare for individuals with neurodegenerative diseases. Moreover, it is vital to provide clinicians and researchers in the neurodegenerative disease fields with resources and infrastructure to ensure continuity of their work during a (health) crisis.
Methods: We established an international collaboration between researchers, clinicians, and patient representatives from the Netherlands, Poland, and the United Kingdom.
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