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Successful venous thrombectomy for extensive cerebral venous and sinus thrombosis after failed diagnostic lumbar puncture.
Rofo
January 2025
Department of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, Germany.
With an incidence of 2-5 per million adults, cerebral venous and sinus thrombosis (CVST) is a rarity in the spectrum of cerebrovascular diseases. The etiology and symptomatic presentation are heterogeneous and diverse. CSVT is, therefore, often underdiagnosed.
View Article and Find Full Text PDFPneumocephalus After Lumbar Epidural Steroid Injection: A Rare Complication With Spontaneous Resolution.
Cureus
November 2024
Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, New York, USA.
Pneumocephalus is a rare but potentially serious complication of spinal procedures, characterized by the presence of intracranial air. This report presents the case of a 40-year-old female who developed pneumocephalus following a lumbar epidural steroid injection. She presented to the emergency department with a persistent headache, blurred vision, and eye pain, which began shortly after the procedure.
View Article and Find Full Text PDFPlasma, brain and spinal cord concentrations of caffeine are reduced in the SOD1 mouse model of amyotrophic lateral sclerosis following oral administration.
Eur J Pharm Biopharm
October 2024
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia. Electronic address:
Article Synopsis
- Modifications to the small intestine and liver during ALS may affect drug absorption, particularly for caffeine, leading to reduced systemic and brain exposure.
- Model drugs were tested on SOD1 mice (ALS model) and wild-type mice to compare pharmacokinetics and intestinal transport mechanisms.
- Results showed that caffeine had significantly lower absorption in SOD1 mice, linked to slower gastric emptying and lower intestinal permeability, suggesting dosage adjustments for ALS patients may be necessary.
Malignant hyperthermia in a paediatric patient; managed successfully without dantrolene: a case report.
Ann Med Surg (Lond)
July 2024
Everest Hospital Pvt Ltd, New Baneshwor, Kathmandu, Nepal.
Introduction: Malignant hyperthermia (MH) is a potentially life-threatening pharmacogenetic syndrome triggered by volatile anaesthetics, succinylcholine, and stress such as vigorous exercise.
Case Presentation: The authors describe a case of an 8-year-old male who presented with classical symptoms of MH after induction of general anaesthesia and symptomatic treatment was done successfully due to the unavailability of Dantrolene.
Discussion: Definitive diagnosis of MH can be done based on a contracture test in fresh muscle biopsy in the presence of halothane and caffeine.
The Plasma Metabolome and Risk of Incident Kidney Stones.
J Am Soc Nephrol
October 2024
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Article Synopsis
- - The study examines the link between plasma metabolomic profiles and the risk of developing kidney stones, revealing that information in this area is currently scarce.
- - Three specific metabolites, including cryptoxanthin and two types of sphingomyelin, showed negative associations with the occurrence of kidney stones in both studied cohorts.
- - The research involved a large sample size of 1,758 participants and used advanced statistical methods to assess the relationships between various metabolites and kidney stone formation risk.
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