PaHB1 (for Picea abies Homeobox1), an evolutionarily conserved HD-GL2 homeobox gene, specifically expressed in the protoderm during somatic embryogenesis in the gymnosperm Norway spruce has been reported previously. An additional HD-GL2 gene designated PaHB2 is reported here. During somatic embryogenesis, the PaHB2 gene is uniformly ex pressed in proembryogenic masses and in early somatic embryos, but it is not detectably transcribed at the beginning of maturation. In mature embryos, PaHB2 expression was essentially detected in the outermost layer of the cortex and the root cap. A similar PaHB2 expression is detected post-embryonically in both the primary root and the hypocotyl. Phylogenetic reconstructions and intron pattern analyses revealed that the PAHB proteins fall within two distinct subclasses comprising highly similar angiosperm homologues. The PAHB1 subclass consists of protoderm/epiderm-specific members. By contrast, the PAHB2 subclass gathers homologues with a subepidermal and protodermal/epidermal activity. This study suggests that at least two distinct HD-GL2 genes with a layer-specific expression already existed in the last common ancestor of angiosperms and gymnosperms. The conserved protodermal/epidermal and subepidermal expression of HD-GL2 genes could be used to study embryo radial pattern formation across seed plants.
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http://dx.doi.org/10.1093/jxb/erg145 | DOI Listing |
Front Immunol
December 2024
Department of General Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: Colorectal cancer (CRC) is a leading cause of cancer-related deaths globally. The heterogeneity of the tumor microenvironment significantly influences patient prognosis, while the diversity of tumor cells shapes its unique characteristics. A comprehensive analysis of the molecular profile of tumor cells is crucial for identifying novel molecular targets for drug sensitivity analysis and for uncovering the pathophysiological mechanisms underlying CRC.
View Article and Find Full Text PDFBMC Plant Biol
December 2024
Institute of Industrial Crops, Shandong Academy of Agricultural Sciences, Jinan, Shandong, 250100, China.
Background: Early-maturity cotton varieties have the potential to be cultivated in a wider geographical area, extending as far north as 46 °N in China, and confer to address the issue of competition for land between grain and cotton by reducing their whole growth period (WGP). Therefore, it is of great importance to develop cotton varieties with comprehensive early maturity and high yield following investigating the regulatory mechanism underlying early maturity and identifying early maturity-related genes.
Results: In this study, 'SCRC19' and 'SCRC21', two excellent cultivars with significantly different WGP, along with their recombinant inbred lines (RILs) consisting of 150 individuals were re-sequenced, yielding 4,092,677 high-quality single nucleotide polymorphisms (SNPs) and 794 bin markers across 26 chromosomes.
Paired-class homeodomain transcription factors (HD TFs) play essential roles in vertebrate development, and their mutations are linked to human diseases. One unique feature of paired-class HD is cooperative dimerization on specific palindrome DNA sequences. Yet, the functional significance of HD cooperative dimerization in animal development and its dysregulation in diseases remain elusive.
View Article and Find Full Text PDFCell Mol Biol (Noisy-le-grand)
November 2024
Betül-Ziya Eren Genome and Stem Cell Center, Erciyes University, Kayseri, Türkiye.
Homeobox (HOX) transcript antisense RNA (HOTAIR) and HOX genes are reported to be more expressed in various cancers in humans in recent studies. The role of HOTAIR and HOXD genes in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) is not well known. In this study, expression levels of HOXD8, HOXD9 and HOXD11 from HOXD gene family and HOTAIR were determined from peripheral blood samples of 30 AML and 30 CML patients and 20 healthy volunteers by quantitative Real Time PCR.
View Article and Find Full Text PDFJ Biol Chem
December 2024
Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, Qingdao 266237, China. Electronic address:
Regulatory-associated protein of TOR (RAPTOR) is a key component of TOR complex 1 (TORC1), which determines the lysosomal location and substrate recruitment of TORC1 to promote cell growth and prevent autophagy. Many studies in recent decades have focused on the posttranslational modification of RAPTOR; however, little is known about the transcriptional regulatory mechanism of Raptor. Using the lepidopteran insect cotton bollworm (Helicoverpa armigera) as model, we reveal the transcriptional regulatory mechanism of Raptor.
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