Unlabelled: Many markers have been proposed to identify the pregnant woman at risk to develop preeclampsia, without finding at the moment the gold standard.
Objective: The main purpose of the present study was to know if the detection of microalbuminuria in early stages of pregnancy is a good predictor of preeclampsia.
Methods And Material: One hundred and two women (102) were studied. All of them had risk factors for preeclampsia with a pregnancy between 16 and 18 weeks, an evaluation of microalbuminuria was done through a clean-catch dipstick of the first miction of the day, excluding patients with urinary tract infections and nephropaty, > 20 mg/L was considered a positive value. Diagnosis data of preeclampsia were recopilated from the clinical chart of each patient after the pregnancy was resolved.
Results: Of the 102 patients, 53 had a negative microalbuminuria, 6 (11%) developed preeclampsia and 47 (88%) did not. Forty nine women had positive microalbuminuria and 23 (46.9%) of them developed preeclampsia and 26 (53%) did not. The sensitivity was 79%, specificity 63%, the positive predictive value was 46% and the negative predictive value was 88%.
Conclusions: The detection of microalbuminuria in early stages of pregnancy could be a good predictor of preeclampsia, moreover it is a simple and feasible procedure to do by the obstetrician.
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Diagnostics (Basel)
December 2024
Gynecology and Obstetric Department, Malatya Turgut Özal Universıty, 44210 Malatya, Turkey.
To compare the levels of podocyte damage markers nephrin and podocalyxin in urine samples taken at the time of gestational diabetes mellitus (GDM) diagnosis and at birth. Amniotic fluid podocalyxin (pdx) and nephrin levels were also analyzed to determine whether GDM had an impact on fetal glomeruli. A total of 50 patients, including 24 patients diagnosed with gestational diabetes and 26 healthy pregnant women whose gestational weeks were matched, were included in the study.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Nephrology, Affiliated Hospital of North Sichuan Medical College, No.1 Maoyuan South Rd, Nanchong, 637000, Sichuan Province, China.
The evidence for the association between the triglyceride (TG) to high-density lipoprotein cholesterol (HDL-c) ratio and the risk of developing microalbuminuria is still limited in the Chinese population. Therefore, our research will endeavor to explore the relationship between the two. The cross-sectional survey enrolled 32,877 general population from eight regional centers in China.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
December 2024
National Health Commission (NHC) Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Pediatr Nephrol
November 2024
Service de Néphrologie Et d'exploration Fonctionnelle Rénale, Hôpital Édouard-Herriot, Hospices Civils de Lyon, Lyon, France.
Am J Transl Res
October 2024
Department of Laboratory, Shanxi University of Traditional Chinese Medicine Affiliated Hospital Taiyuan 030024, Shanxi, China.
Objective: To explore the correlation between serum interleukin-22 (IL-22) and interleukin-27 (IL-27) levels and vasculopathy in patients with diabetic nephropathy (DN).
Methods: A total of 104 DN patients treated at the Shanxi University of Traditional Chinese Medicine Affiliated Hospital were selected as the observation group, with another 104 healthy individuals, serving as the control group in this retrospective study. The baseline data and the serum levels of IL-22 and IL-27 were compared between the two groups.
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