Introduction: The reference value for and the significance of mild thrombocytopenia associated with pregnancy remain undetermined, and therefore the timing, validity and meaning of coagulation tests before a regional block may vary.
Objective: To determine whether the incidence of bloody puncture is related to preoperative platelet count performed just before an epidural block, to review the incidence of hemorrhagic complications and to determine whether such complications are related to preoperative platelet count.
Methods: We carried a retrospective study of computer records for 1,168 patients given regional blocks to control pain during labor. A blood sample was obtained to assess the platelet count immediately before the block; we then analyzed the correlation between the incidence of bloody puncture and platelet count, with the patients distributed in 4 groups according to the latter.
Results: The platelet count of most patients fell between 150,000 and 250,000/mm3. The second largest group had counts between 100,000 and 150,000 platelets/mm3, which would constitute mild thrombocytopenia in non-pregnant patients. Seventy-two bloody punctures were observed, for an incidence of 6.16%, and the incidence was significantly higher in the group of patients with over 350,000 platelets/mm3 (p < 0.05). No severe obstetrical complications, such as obstetric hysterectomy or severe postpartum bleeding occurred. Nor were there cases of epidural hematoma.
Conclusions: A complete clinical history must be obtained during the anesthetist's interview with the patient in the last month of pregnancy, and detailed information on the risk of regional blocks during labor must be offered. When blood tests at the time of the interview are normal and the clinical history indicates low risk, repeating tests immediately before the block is unjustified, provided the clinical situation does not change.
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Background And Aim: There is paucity of data about the prevalence of cirrhosis and portal hypertension in the US general population.
Methods: We used National Health and Nutrition Examination Surveys (NHANES 2017-2020) to estimate the prevalence of cirrhosis and clinically significant (CS)-portal hypertension in alcoholic liver disease (ALD), MetALD, viral hepatitis (VH) to include chronic hepatitis B (CHB) and chronic hepatitis C (CHC), and metabolic dysfunction-associated steatotic liver disease (MASLD). Cirrhosis was evaluated using liver stiffness measurement (LSM) by transient elastography or FIB-4 score; CS-portal hypertension was defined via LSM and platelet count or the use of non-selective beta-blockers in the presence of cirrhosis.
J Clin Hypertens (Greenwich)
January 2025
Department of Obstetrics and Gynecology, Women and Children's Hospital of Chongqing Medical University, Chongqing, China.
Hemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome is a severe complication of preeclampsia (PE), with a higher incidence rate in people living at high altitudes, such as Tibet area. Maternal HELLP syndrome is associated with an elevated neonatal mortality rate. The purpose of this study was to investigate the predicting factors for neonatal outcomes with maternal HELLP syndrome.
View Article and Find Full Text PDFClin Spine Surg
January 2025
Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine.
Study Design: Retrospective cohort study using prospective database.
Objective: This study aimed to establish a risk-scoring system for predicting severe complications after pyogenic spondylodiscitis surgery.
Summary Of Background Data: Pyogenic spondylodiscitis surgery can cause severe complications.
J Clin Hypertens (Greenwich)
January 2025
Department of Cardiology, Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
The platelet-to-lymphocyte ratio (PLR) has been proposed as a promising inflammatory biomarker, with potential implications for cardiovascular prognosis. However, its association with mortality outcomes in hypertensive individuals is not fully elucidated. This investigation sought to clarify the linkage between PLR and both overall and cardiovascular mortality in hypertensive individuals.
View Article and Find Full Text PDFClin Pediatr (Phila)
February 2025
Department of Biochemistry, University Children's Hospital Belgrade, Beograd, Serbia.
Immune thrombocytopenic purpura (ITP) is an acquired immune-mediated bleeding disorder characterized by isolated low platelet (PLT) counts. Immune thrombocytopenic purpura pathogenesis involves multiple immune mechanisms causing PLT destruction and inadequate production. Owing to impaired immune homeostasis, ITP patients can develop other than anti-PLT autoantibodies even in the absence of clinical signs of autoimmune disease, such as anti-thyroglobulin (TG) and anti-thyroperoxidase (TPO) antibodies.
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