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Indications for the use of dermal substitutes in patients with acute burns and in reconstructive surgery after burns: A systematic review.
Wound Repair Regen
December 2024
Alliance of Dutch Burn Care (ADBC), Burn Centre, Red Cross Hospital, Beverwijk, The Netherlands.
Deep dermal and full-thickness burns often result in scar sequelae such as contractures, hypertrophy, pain and itching following split-thickness skin grafting. Dermal substitutes are currently employed alongside split-thickness skin grafting to enhance clinical outcomes, though their indications remain a subject of ongoing debate. This systematic review aims to clarify the indications for the application of dermal substitutes in burn patients, in both acute and reconstructive settings.
View Article and Find Full Text PDFMagnitude of infection and associated factors in open tibial fracture treated operatively, in Addis Ababa burn emergency and trauma center.
Eur J Orthop Surg Traumatol
December 2024
Saint Paul hospital Millenium Medical College, Addis Ababa, Ethiopia.
Background: Due to the specific anatomical features of the tibia (limited soft tissue coverage), more than a quarter of its fractures are classified as open, representing the most common open long-bone injuries. Open tibial fractures frequently cause significant bone comminution, periosteal stripping, soft tissue loss, contamination and are prone to bacterial entry with biofilm formation, which increases the risk of deep bone infection. The main objective of this study was to determine prevalence of infection and its associated factors in surgically treated open tibial fracture, at Addis Ababa Burn Emergency and Trauma (AaBET) hospital.
View Article and Find Full Text PDFRevealing the Therapeutic Potential of Stem Cells in Burn Healing: A Deeper Understanding of the Therapeutic Mechanisms of Epidermal Stem Cells and Mesenchymal Stem Cells.
Stem Cells Int
December 2024
Department of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China.
Burns are a global public health issue and a major cause of disability and death around the world. Stem cells, which are the undifferentiated cells with the potential for indefinite proliferation and multilineage differentiation, have the ability to replace injured skin and facilitate the wound repair process through paracrine mechanisms. In light of this, the present study aims to conduct a bibliometric analysis in order to identify research hotspots of stem cell-related burns and assess global research tendencies.
View Article and Find Full Text PDFExosome laden sprayable thermo-sensitive polysaccharide-based hydrogel for enhanced burn wound healing.
Int J Biol Macromol
December 2024
Nano Drug Delivery Systems (NDDS), Cancer Biology Division, Rajiv Gandhi Centre for Biotechnology (BRIC-RGCB), Thycaud P.O, Poojappura, Thiruvananthapuram, Kerala 695014, India. Electronic address:
Severe burns pose significant threats to patient well-being, characterized by pain, inflammation, bacterial infection, and extended recovery periods. While exosome-loaded hydrogels have demonstrated considerable promise in wound healing, current formulations often fall short of achieving optimal therapeutic efficacy for burn wounds due to challenges related to their adaptability to wound shape and limited anti-bacterial capabilities. In this study a novel exosome laden sprayable thermosensitive polysaccharide-based hydrogel (ADA-aPF127@LL18/Exo) comprising alginate dialdehyde (ADA) and aminated Pluronic F127 (aPF127) was fabricated via Schiff base reaction.
View Article and Find Full Text PDFRole of artificial intelligence in treatment planning and outcome prediction of jaw corrective surgeries by using 3-D imaging-a systematic review.
Oral Surg Oral Med Oral Pathol Oral Radiol
October 2024
Department of Translational Medicine, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
Objective: Artificial intelligence (AI) has been increasingly utilized in diagnosis of skeletal deformities, while its role in treatment planning and outcome prediction of jaw corrective surgeries with 3-dimensional (3D) imaging remains underexplored.
Methods: The comprehensive search was done in PubMed, Google scholar, Semantic scholar and Cochrane Library between January 2000 and May 2024. Inclusion criteria encompassed studies on AI applications in treatment planning and outcome prediction for jaw corrective surgeries using 3D imaging.
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