AI Article Synopsis
- The Spontaneously Diabetic Torii (SDT) rat is a new model for studying nonobese type 2 diabetes, showing glucose intolerance and complete diabetes incidence by 38 weeks.
- Researchers conducted a quantitative trait locus (QTL) analysis and identified three significant QTLs linked to glucose intolerance on chromosomes 1, 2, and X.
- These results highlight the polygenic nature of diabetes in SDT rats, suggesting that they could help deepen our understanding of the genetics behind human type 2 diabetes.
Article Abstract
The Spontaneously Diabetic Torii (SDT) rat has recently been established as a new rat model of nonobese type 2 diabetes. In this study, we characterized diabetic features in SDT rats, and performed quantitative trait locus (QTL) analysis for glucose intolerance using 319 male (BNxSDT)xSDT backcrosses. Male SDT rats exhibited glucose intolerance at 20 weeks, and spontaneously developed diabetes with the incidence of 100% at 38 weeks, and glucose intolerance is well associated with the development of diabetes. The QTL analysis identified three highly significant QTLs (Gisdt1, Gisdt2, and Gisdt3) for glucose intolerance on rat chromosomes 1, 2, and X, respectively. The SDT allele for these QTLs significantly exacerbated glucose intolerance. Furthermore, synergistic interactions among these QTLs were detected. These findings indicate that diabetic features in SDT rats are inherited as polygenic traits and that SDT rats would provide insights into genetics of human type 2 diabetes.
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| http://dx.doi.org/10.1016/s0006-291x(03)00548-5 | DOI Listing |
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