In periodontal treatment the importance of self-performed plaque control is frequently acknowledged but often underestimated. This article reviews the evidence relating to the effects of good oral hygiene on both the initiation and progression of gingivitis and periodontitis, and on treatment outcomes. Recent evidence suggests that an optimal level of supragingival plaque control can have profound effects on the subgingival microflora and this, together with evidence indicating that root surface microbial contaminants are superficially located within the biofilm, has significant therapeutic implications.
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http://dx.doi.org/10.12968/denu.2003.30.2.60 | DOI Listing |
Arch Dermatol Res
January 2025
Periodontology Department, Faculty of Dentistry, Van Yüzüncü Yıl University, Van, Turkey.
The purpose of this study was to determine the levels of IL-17, Bcl-3 and IκBζ gene expression in the gingival crevicular fluid (GCF) of psoriatic and healthy individuals and to compare the clinical periodontal parameters in the patient and control groups. A total of 10 psoriasis patients and 2 healthy patients in the control group were included in the analysis for IL-17, Bcl-3, and IκBζ gene expression in the GCF. Periodontal health, gingival index, plaque index, and mobility (using a periotest device) levels were compared between the groups.
View Article and Find Full Text PDFClin Oral Investig
January 2025
University Hospital for Conservative Dentistry and Periodontology, Medical University of Innsbruck, Innsbruck, 6020, Austria.
Objectives: To compare the plaque reducing efficacy of oil pulling with sesame oil compared to distilled water in a randomized, controlled, examiner-blinded parallel group study.
Materials And Methods: Forty probands without advanced periodontal disease of the University Hospital for Restorative Dentistry and Periodontology, Medical University of Innsbruck (Austria) were randomized allocated to test- (sesame oil) or control group (distilled water) and asked to pull daily in the morning for eight weeks with their allotted fluid for 15 min. Rustogi Modified Navy Plaque Index (RMNPI) and gingival bleeding index were assessed at baseline and after four and eight weeks.
Alzheimers Dement
December 2024
Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA; NYU Langone Health, New York, NY, USA.
Background: Clinical and preclinical evidence suggest that abnormal electrical activity strongly impacts outcomes in Alzheimer's disease (AD). Indeed, AD patients with interictal spikes (IIS) show faster cognitive decline than those without IIS. Furthermore, seizures in patients with AD have been suggested to accelerate disease progression.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
All India Institute of Medical Sciences, New Delhi, New Delhi, India.
Background: Alzheimer's disease (AD) is a neurodegenerative disease characterized by Aβ plaques and neurofibrillary tangles, with chronic inflammation and synaptic dysfunction playing a significant contributor to disease progression and cognitive decline. Small extracellular vesicles (sEVs) are implicated in AD progression by facilitating the spread of pathological proteins and inflammatory cytokines. This study investigates the role of plasma-derived sEVs (PsEVs) in synaptic dysfunction and neuroinflammation and their association with amyloid-β and tau pathologies in AD progression.
View Article and Find Full Text PDFBackground: Seizures maybe associated with worse neuropathology findings in people with dementia. However, the role of seizure control and how it may impact post-mortem histopathology findings in people with dementia remains unexplored.
Method: We used the longitudinal, multicenter National Alzheimer Coordinating Center data from 9/2005 to 12/2021 to evaluate the association between seizure control and histopathological neurodegenerative changes in people with dementia.
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