True cyclopia is a rare anomaly in which the organogenetic development of the 2 separate eyes is suppressed. We report a fetus with an association of cyclopia with other anomalies. The possible mechanism of the histogenesis is discussed, together with a review of the relevant literature.
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The human brain and face: mechanisms of cranial, neurological and facial development revealed through malformations of holoprosencephaly, cyclopia and aberrations in chromosome 18.
J Anat
September 2015
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
The study of inborn genetic errors can lend insight into mechanisms of normal human development and congenital malformations. Here, we present the first detailed comparison of cranial and neuro pathology in two exceedingly rare human individuals with cyclopia and alobar holoprosencephaly (HPE) in the presence and absence of aberrant chromosome 18 (aCh18). The aCh18 fetus contained one normal Ch18 and one with a pseudo-isodicentric duplication of chromosome 18q and partial deletion of 18p from 18p11.
View Article and Find Full Text PDFTrue cyclopia-very rare anomaly.
J Clin Diagn Res
August 2014
Professor, Department of Pathology, Vinayaka Missions Kirupananda Variyar Medical College, Salem, Tamilnadu, India .
During our routine postmortem examination, we found a female infant with "True Cyclopia." The two entire eye balls had fused completely to form one midline organ. The infant was a female who weighed 2910 g.
View Article and Find Full Text PDFDifferentiation of true anophthalmia from clinical anophthalmia using neuroradiological imaging.
World J Radiol
July 2014
Ali Riza Cenk Celebi, Ophthalmology Clinic, Republic of Turkey Ministry of Health, Nigde State Hospital, Nigde 51000, Turkey.
Anophthalmia is a condition of the absence of an eye and the presence of a small eye within the orbit. It is associated with many known syndromes. Clinical findings, as well as imaging modalities and genetic analysis, are important in making the diagnosis.
View Article and Find Full Text PDFCongenital disorder of true cyclopia with polydactylia: case report and review of the literature.
Clin Exp Obstet Gynecol
January 2014
Department of Pharmacology, Democritus University of Thrace, Alexandroupolis, Greece.
Cyclopia is a rare type of holoprosencephaly and a congenital disorder characterized by the failure of the embryonic forebrain to properly divide the orbits of the eye into two cavities (the embryonic forebrain is normally responsible for inducing the development of the orbits). As a result a birth defect in which there is only one eye is developed. This eye is centrally placed in the area normally occupied by the root of the nose.
View Article and Find Full Text PDFCyclops are among the best-known monsters of Greek mythology, also mentioned in art and literature. According to the most recent scientific knowledge, the malformations caused by defective development of the anterior brain and midline mesodermal structures include cyclopia (synophthalmos), ethmocephaly, cebocephaly and arrhinencephaly. These severe forebrain lesions often are accompanied by severe systemic malformations, and affected infants rarely survive.
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