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Chronic coronary syndrome in Africa: current management and service challenges, and opportunities for optimizing patient care.
J Cardiovasc Med (Hagerstown)
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St George's Hospitals NHS Trust University of London, London, UK.
African populations have traditionally been considered at relatively low risk of cardiovascular diseases (CVD), such as chronic coronary syndrome (CCS), but this is rapidly changing in association with ageing populations, uncontrolled urbanization and lack of control of classical CV risk factors. In sub-Saharan Africa, CVD deaths have increased by more than 50% in the past three decades. For CCS care, limited availability of clinical expertise, diagnostic facilities, and access to optimal medical therapy (OMT), lack or inadequate reimbursement of healthcare costs, and scarcity of universal health coverage (UHC) are major challenges.
View Article and Find Full Text PDFLipid Dysregulation in Tangier Disease: A Case Series and Metabolic Characterization.
J Clin Endocrinol Metab
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Department of Internal Medicine, General Hospital Oberndorf, Teaching Hospital of the Paracelsus Medical University Salzburg, Oberndorf, Salzburg, Austria.
Context: Tangier disease (TD) is a rare, autosomal recessive genetic disorder associated with a deficiency in cellular cholesterol export leading to cholesterol accumulation in peripheral tissues. With approximately 150 described cases, the disease is significantly understudied, and the clinical presentation appears to be heterogenous.
Objective: To investigate the phenotype and lipid metabolism in TD.
The Myositis Clinical Trials Consortium: an international collaborative initiative to promote clinical trials in adult and juvenile myositis.
Clin Exp Rheumatol
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Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Idiopathic inflammatory myopathies (IIM), or myositis, are a heterogeneous group of systemic autoimmune disorders that are associated with significant morbidity and mortality. Conducting high-quality clinical trials in IIM is challenging due to the rare and variable presentations of disease. To address this challenge, the Myositis Clinical Trials Consortium (MCTC) was formed.
View Article and Find Full Text PDFDiagnostic Power of the CD4+/CD8+ Ratio and the Expression of Activation and Memory Markers in Differentiating Sarcoidosis from Tuberculosis, Idiopathic Pulmonary Fibrosis, and Other Interstitial Lung Diseases.
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Higher Institute of Nursing Professions and Health Techniques in Rabat, Ministry of Health and Social Protection, Rabat, Morocco.
Background: Sarcoidosis is a complex inflammatory disease of unknown etiology affecting mostly the lungs and poses a significant diagnostic challenge, particularly in regions where tuberculosis (TB) is endemic. The diagnostic complexity intensifies due to shared clinical and radiological features between sarcoidosis and TB, as well as similarities with idiopathic pulmonary fibrosis (IPF) in cases that progress to pulmonary fibrosis. Accurately distinguishing between these diseases is critical for timely and effective patient management.
View Article and Find Full Text PDFUnlocking the potential of serious games for rehabilitation in low and middle-income countries: addressing potential and current limitations.
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