To show the efficacy of an allogenic bone graft in elective foot surgery, the authors report on 39 consecutive procedures in which allograft was implanted in 26 patients during a 30-month period. These procedures were performed for a variety of conditions, including arthrodesis, segmental lengthening, and treatment of nonunion. Allograft material consisted of freeze-dried tricortical iliac crest or demineralized bone matrix used either alone or as a composite. Allograft incorporation in all surgical procedures was retrospectively analyzed. Of 39 consecutive implant procedures, there were 38 healed sites (97%) and 1 nonunion (3%). After radiographic and clinical evaluation of allograft incorporation, the authors conclude that allogenic bone graft is a viable option for a multitude of foot conditions.
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http://dx.doi.org/10.1016/s1067-2516(03)70006-4 | DOI Listing |
Cytotherapy
December 2024
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China. Electronic address:
We conducted a systematic review and meta-analysis to evaluate the outcomes of Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) in the treatment of Shwachman-Diamond syndrome (SDS). A literature search was performed on PubMed, Embase, and Web of Science. After screening 397 articles, 10 studies were included.
View Article and Find Full Text PDFTheranostics
January 2025
Department of Internal Medicine III, School of Medicine and Health, Technical University of Munich, Munich, Germany.
Despite recent advances in the targeted therapy of AML, the disease continues to have a poor prognosis. Allogeneic hematopoietic stem cell transplantation (alloSCT) remains to be the curative therapy option for fit patients with high-risk disease. Especially patients with relapsed or refractory (r/r) AML continue to have poor outcomes.
View Article and Find Full Text PDFZhongguo Shi Yan Xue Ye Xue Za Zhi
December 2024
Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University,Beijing 100044, China.
Objective: To evaluate the gene mutation profile and prognostic significance of adult cytogenetically normal acute myeloid leukemia (CN-AML) with mutation.
Methods: Targeted sequencing was implemented on the diagnostic bone marrow DNA samples of 141 adult CN-AML subjects with mutation. The nomogram model for leukemia-free survival (LFS) rate was generated by combining genetic abnormalities and clinical data.
Exp Neurol
December 2024
Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA; Stanford Stroke Center, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:
Despite substantial advances in the acute management of stroke, it remains a leading cause of adult disability and mortality worldwide. Currently, the reperfusion modalities thrombolysis and thrombectomy benefit only a fraction of patients in the hyperacute phase of ischemic stroke. Thus, with the exception of vagal nerve stimulation combined with intensive physical therapy, there are no approved neuroprotective/neurorestorative therapies for stroke survivors.
View Article and Find Full Text PDFEBioMedicine
December 2024
Department of Hematology and Cell Therapy, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang province, PR China. Electronic address:
Background: Bronchiolitis obliterans syndrome (BOS) is one of the most devastating outcomes of chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). This remains an area of unmet clinical need for optimal therapy for BOS patients partly due to the limited understanding of pathogenic mechanisms.
Methods: We collected blood samples from 22 patients with cGVHD and 11 patients without cGVHD following allo-HSCT.
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