Background: Lichen planus (LP) is a common inflammatory dermatosis the diagnosis of which can be very complex when it affects the female genital area exclusively. The condition should be managed by both dermatologists and gynecologists because the association between vulvar LP and other immune-mediated disorders occurs frequently.
Case: Vulvar LP was diagnosed in 37-year-old woman whose past history was significant for ulcerative colitis (UC) since the age of 21. The oral mucosa and skin were completely unaffected, but whitish papules and plaques were seen diffusely on the whole vulvar region, which had become sclerotic and edematous. Microscopic examination of lesional tissue confirmed the diagnosis, showing classic histologic features in spite of the mixed and hypertrophic clinical variant. Oral therapy with cyclosporin at an initial dose of 250 mg/d led to complete remission within 3 months.
Conclusion: This case is reported on for the rarity of isolated vulvar involvement by LP and for the excellent response to treatment.
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Int J Surg Case Rep
December 2024
Institut de Cancérologie de Lorraine, 6 avenue de Bourgogne, 54519 Vandœuvre-lès-Nancy, France; CRAN, CNRS, UMR 7039, Université de Lorraine, Vandœuvre-lès-Nancy, France.
Introduction And Importance: Lichen planus is an inflammatory and chronic disease with multifactorial causes. Hypertrophic subtype of lichen planus is an extremely rare lesion when found in the larynx. This article describes the case of a man with such a lesion.
View Article and Find Full Text PDFClin Exp Dermatol
January 2025
Institute of Dentistry, School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen, UK.
Background: The limited understanding of factors influencing the disease progression of oral lichen planus (OLP) poses challenges in delivering effective and personalised treatment for this condition, known to increase the risk of oral cancer and adversely impact patient quality of life.
Objective: This study aimed to systematically identify clinical predictors of disease severity in OLP patients.
Methods: This cross-sectional and single-site prospective study was conducted between December 2021 and February 2024 in the Departments of Oral Medicine and Oral & Maxillofacial Surgery, Aberdeen Royal Infirmary.
J Invest Dermatol
December 2024
Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany; Department of Dermatology, Ludwig-Maximilians University Hospital, Munich, Germany. Electronic address:
Lichen planus (LP) is a chronic inflammatory disease (ISD) affecting skin, mucosa, nail, and hair. Previous studies demonstrated a pivotal role of type 1 immunity in LP, as infiltrating T cells trigger apoptosis and necroptosis in the epidermis. In this study, we investigated the role of DAPK1 in LP with special focus on its role in mediating cell death and inflammation.
View Article and Find Full Text PDFCureus
December 2024
Department of Obstetrics and Gynecology, Sendai City Hospital, Sendai, JPN.
Lichen planus is an inflammatory disease that affects the skin and mucous membranes, and although rare, it can manifest in the vulvar region. Vulvar lichen planus can occur in women of reproductive age and may cause vulvar adhesion, potentially complicating examinations and delivery during pregnancy. We report a case in which a pregnant woman with vulvar adhesion due to vulvar lichen planus successfully delivered vaginally following labiaplasty.
View Article and Find Full Text PDFArch Oral Biol
December 2024
Programa de Pós-Graduação em Ciências Odontológicas, Universidade Federal do Espírito Santo (UFES), Brazil. Electronic address:
Objectives: This study aimed to compare clinicopathological features and immunostaining for cytokeratin-10 between oral lichen planus and oral lichenoid lesions.
Design: This was a retrospective longitudinal study comparing lichen planus and oral lichenoid lesions diagnosed at the Oral Pathological Anatomy Service that analyzed sociodemographic and clinicopathological data and CK10 expression. Chi-square tests, Fisher's exact tests and Mann-Whitney tests or Student's t tests were used when appropriate, and p values < 0.
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