Tail-suspension (TS) in the rat represents an interesting experimental condition to mimic, on Earth, the microgravity-induced cardiovascular deconditioning although the rat's profile of response is partially different from human's. To investigate underlying pathophysiological mechanisms, we have speculated on a decreased activity of the sympathetic system, (sigma S) triggered by the increase of the central venous pressure (CVP) induced by TS. Thus a decreased activity of the sigma S could account, at least partly, for the deconditioning of the cardiovascular system. The sympathetic activity (sigma A) was evaluated through measurement of the norepinephrine (NE) kinetics in rats that were tail-suspended for either 6, 24 or 48 hours. Neither NE spillover rate nor metabolic clearance rate were changed during TS, as compared to control. Thus, TS for a short period of time in the rat is unlikely to trigger a decrease of the sigma A.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Integrating network pharmacology with molecular docking and dynamics to uncover therapeutic targets and signaling mechanisms of vitamin D3 in Parkinson's disease.
Mol Divers
January 2025
School of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang, People's Republic of China.
Parkinson's disease (PD) is a chronic neurodegenerative disorder marked by dopaminergic neuron degeneration in the substantia nigra. Emerging evidence suggests vitamin D3 (VD) plays a therapeutic role in PD, but its precise molecular mechanisms remain unclear. This study employed network pharmacology and bioinformatics to identify VD's hub targets and related pathways.
View Article and Find Full Text PDFDiosgenin loaded-chitosan biodegradable nanoparticles ameliorate adjuvant-induced arthritis, pain, and peripheral neuropathy through moderation of inflammatory and oxidative stress biomarkers.
Int J Biol Macromol
December 2024
Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore Campus, Lahore 38000, Pakistan. Electronic address:
This research work was designed to develop efficient Diosgenin (DGN) loaded biodegradable nanoparticles (DGN-NPs) for treating rheumatoid arthritis. The DGN-NPs were synthesized by ionic-gelation method using chitosan as a biodegradable polymer and in-vitro release study was performed followed by kinetics study. DGN-NPs had an average size of 290 nm, zeta potential of +11.
View Article and Find Full Text PDFPostprandial hypoglycaemia after gastric bypass in type 2 diabetes: pathophysiological mechanisms and clinical implications.
Diabetologia
February 2025
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Article Synopsis
- Postprandial hypoglycaemia (PPHG) is a common complication after Roux-en-Y gastric bypass (RYGB) in individuals with a history of type 2 diabetes, often occurring without symptoms.
- A study of 24 patients showed that PPHG results from an excessive clearance of glucose and hyperinsulinaemia, linked to higher insulin sensitivity and enhanced beta cell function.
- Those experiencing PPHG had poor hormonal responses to low blood sugar, leading to more frequent and prolonged hypoglycaemia, which affected their eating habits over time.
Population Pharmacokinetic Modelling of Norepinephrine in Healthy Volunteers Prior to and During General Anesthesia.
Clin Pharmacokinet
November 2024
Department of Anaesthesiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
Article Synopsis
- Intraoperation hypotension (IOH) during surgery can have negative effects, leading to the routine use of norepinephrine (NE) to manage blood pressure under general anesthesia, although its pharmacokinetics during such conditions are not well understood.
- The study aimed to analyze the pharmacokinetics of NE in healthy volunteers in both awake and general anesthesia states, using a step-up dosing method and measuring plasma concentrations.
- Results indicated that a two-compartment model effectively described NE dynamics, finding that general anesthesia reduced NE clearance by 10%, with weight, age, and session (awake vs. anesthesia) being significant factors affecting its clearance.
Morphine sulfate nano-controlled release microspheres effectively relieve visceral pain caused by tumor in mice.
Am J Transl Res
September 2024
Department of Pain, Beijing Jishuitan Hospital, Capital Medical University Beijing 100035, China.
Article Synopsis
- The study focused on the effectiveness of morphine sulfate nano-controlled release microspheres in alleviating visceral pain caused by tumors in mice models.
- Researchers used various experimental groups to compare the pain-relief effects of morphine-loaded microspheres with a control group and found significant reductions in pain responses and improved pain thresholds among the treated groups.
- Results indicated a high drug release rate from the microspheres, and the treatment led to notable changes in neurotransmitter levels in the brain linked to pain perception, with no significant adverse side effects observed.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!