A fibrinogen variant was identified in a pregnant patient with disseminated intravascular coagulation and abruptio placentae. This dysfibrinogen was also found in four asymptomatic members of the patient's family. Coagulation studies showed prolongation of both the thrombin and reptilase times, and discrepancy was noted between the levels of plasma fibrinogen as determined by a kinetic versus an immunological determination or light-scattering assay. Studies on purified fibrinogen revealed an impaired release of fibrinopeptide B by thrombin related to a delayed thrombin-induced fibrin polymerization. DNA sequencing revealed a heterozygous T <-- A point mutation in position 9373 of the gamma-chain gene (exon 9), which substituted a K for an N at position 361.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/01.mbc.0000061286.28953.65 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Risk factors for plastic bronchitis in children with macrolide-unresponsive pneumonia and establishment of a nomogram model].
Zhongguo Dang Dai Er Ke Za Zhi
January 2025
Department of Pediatrics, Provincial Hospital Affiliated to Fuzhou University/Fujian Provincial Hospital, Fuzhou 350001, China.
Objectives: To investigate the risk factors for plastic bronchitis (PB) in children with macrolide-unresponsive pneumonia (MUMPP) and to establish a nomogram prediction model.
Methods: A retrospective analysis was conducted on 178 children with MUMPP who underwent bronchoscopy from January to December 2023. According to the presence or absence of PB, the children were divided into a PB group (49 children) and a non-PB group (129 children).
Nucleotide sequence variants, gene expression and serum profile of immune and antioxidant markers associated with brucellosis resistance/susceptibility in Shami goat.
Ir Vet J
January 2025
Animal and Poultry Production Division, Department of Animal and Poultry Breeding, Desert Research Center, Cairo, Egypt.
Brucellosis is a highly contagious zoonotic bacterial disease. It has considerable negative consequences on the animal production industry worldwide. The objective of this study was to investigate the genetic and molecular variations in Shami goat susceptible to Brucella infection.
View Article and Find Full Text PDFBiological testing unification for hemodialysis membranes evaluation: A step towards standardization.
Biomater Adv
January 2025
Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Mexico. Electronic address:
Current hemodialysis treatments can cause adverse effects, many of which are linked to the membranes used in the process. These issues are being addressed through new materials and technologies, making it urgent to establish minimum guidelines for evaluating such membranes. This review proposes standardizing the biological tests and variables to evaluate the performance of new membranes, aiming to replicate hemodialysis conditions closely.
View Article and Find Full Text PDFDisseminated intravascular coagulation: cause, molecular mechanism, diagnosis, and therapy.
MedComm (2020)
February 2025
Department of Emergency Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China.
Disseminated intravascular coagulation (DIC) is a complex and serious condition characterized by widespread activation of the coagulation cascade, resulting in both thrombosis and bleeding. This review aims to provide a comprehensive overview of DIC, emphasizing its clinical significance and the need for improved management strategies. We explore the primary causes of DIC, including sepsis, trauma, malignancies, and obstetric complications, which trigger an overactive coagulation response.
View Article and Find Full Text PDFEfficacy of three predictive models for deep vein thrombosis in patients with lumbar disc herniation.
Am J Transl Res
December 2024
Department of Traditional Chinese Medicine, The First Hospital of Hebei Medical University Shijiazhuang 050091, Hebei, China.
Objective: To develop predictive models for assessing deep vein thrombosis (DVT) risk among lumbar disc herniation (LDH) patients and evaluate their performances.
Methods: A retrospective study was conducted on 798 LDH patients treated at the First Hospital of Hebei Medical University from January 2017 to December 2023. The patients were divided into a training set (n = 558) and a test set (n = 240) using computer-generated random numbers in a ratio of 7:3.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!