AI Article Synopsis
- Atypical myeloproliferative disorder (aMPD) is a rare condition linked to chromosomal translocations on chromosome 8, specifically involving a t(8;13)(p12;q12) that combines the fibroblast growth factor receptor 1 gene with the FIM/ZNF198 gene.
- Patients often have a poor prognosis, typically progressing to acute myeloid leukemia within 1 year of diagnosis.
- The study reports a patient achieving complete remission 39 months post-allogeneic bone marrow transplantation, marking the first documented case of molecular remission in this disorder.
Article Abstract
A rare atypical myeloproliferative disorder (aMPD) associated with chromosomal translocations involving the short arm of chromosome 8, region p11-p12 has been described. In most patients, the cytogenetic abnormality is a t(8;13)(p12;q12) that fuses fibroblast growth factor receptor 1, the 8p12 key gene, to FIM/ZNF198 gene. Prognosis is poor with frequent evolution to acute myeloid leukaemia within 1 year of diagnosis. We report a new patient with aMPD with a t(8;13) translocation. Complete haematological, cytogenetic and molecular remission was demonstrated 39 months after allogeneic bone marrow transplantation. This is the first report to demonstrate a molecular remission in this disorder.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1046/j.1365-2141.2003.04269.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!