Unlabelled: We studied the possibility and safety of a new approach to breast-feeding infants with phenylketonuria (PKU). We compared a group of PKU infants being breast-fed according to our new protocol with a group of PKU infants receiving formula only. The breast-fed group consisted of nine infants born between 1994 and 1999 being breast-fed at the time of diagnosis. The formula-fed group consisted of nine PKU infants, born between 1988 and 1997. In the breast-fed group, feedings alternated between breast-feeding and phenylalanine (Phe)-free bottle-feeding. The numbers of breast-feedings were adapted to the plasma Phe concentrations. At each feeding, either bottle- or breast-feeding, the child was allowed to drink until satiety. Data on metabolic control and growth during the first 6 months showed no statistically different results. The mean Phe concentration in the breast- fed group was 170 micro mol/l (range 137-243 micro mol/l) and in the formula- fed group 181 micro mol/l (range 114-257 micro mol/l). Compared to a routine where both bottle and breast are offered at each feeding, this new approach is more convenient for the parents and the child will be able to empty the breast, therefore drinking not only foremilk but also hindmilk.
Conclusion: the results suggest that this feeding protocol is safe in the strict treatment of otherwise healthy infants with phenylketonuria.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00431-003-1182-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Improved toughening attributes of coix seed oil high internal phase Pickering emulsion gel via the carrageenan and super-deamidated wheat gluten microparticles interfacial network fotified by the acid-heat induction strategy.
Int J Biol Macromol
January 2025
Guangdong Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan, Guangdong, 528225, People's Republic of China; School of Food Science and Engineering, Foshan University, Foshan, Guangdong 528000, People's Republic of China. Electronic address:
The toughening coix seed oil (CSO) high internal phase Pickering emulsion (CSO-HIPES) and gel (CSO-HIPESG) comprised of carrageenan (CR)/super-deamidated-gluten (SDG) micro-particles (CR/SDG) were investigated via acid-heat induction. Results showed polysaccharide natural deep eutectic solvent (P-NADES) by citric acid-glucose-carrageenan ((CGCR), molar ratio at 1:1:0.035) was the crucial for the preparation of SDG (deamidation degree, 99.
View Article and Find Full Text PDFFeNi-Based Aerogels Containing FeNi Nanoclusters Embedded with a Crystalline-Amorphous Heterojunction as High-Efficiency Oxygen Evolution Catalysts.
Molecules
November 2024
School of Mechanical Engineering, Chengdu University, Chengdu 610106, China.
In green hydrogen production via water electrolysis, catalysts with multiscale nanostructures synthesized by compositing micro-heterojunctions and nanoporous structures exhibit excellent electrocatalytic oxygen evolution reaction (OER) performance. Moreover, they are the most promising non-noble metal catalysts. Herein, FeNi-based aerogels with a three-dimensional nanoporous structure and amorphous matrix embedded with FeNi nanoclusters were synthesized via wet chemical reduction coprecipitation.
View Article and Find Full Text PDFUnveiling the antiglioblastoma potential of harmicens, harmine and ferrocene hybrids.
Acta Pharm
December 2024
University of Zagreb Faculty of Pharmacy and Biochemistry, 10 000 Zagreb, Croatia.
The poor prognosis of glioblastoma multiforme, inadequate treatment options, and growing drug resistance urge the need to find new effective agents. Due to the significant anti-cancer potential of harmicens, hybrid compounds which comprise harmine/β-carboline and ferrocene moiety, we investigated their antiglioblastoma potential and mechanism of action (inhibition of DYRK1A, Hsp90, anti-oxidative activity). The results have shown that triazole-type harmicens, namely , with a ferrocene moiety in C-3 position of the β-carboline ring ( = 3.
View Article and Find Full Text PDFSimultaneous quantification of serum symmetric dimethylarginine, asymmetric dimethylarginine and creatinine for use in a routine clinical laboratory.
Ann Clin Biochem
November 2024
Department of Clinical Biochemistry, Manchester University NHS Foundation Trust, Manchester, UK.
Background: Symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA) are naturally occurring amino acids classed as uraemic toxins by the European Uremic Toxins Work Group. SDMA is principally excreted through the kidneys and is a well-known renal function marker, and ADMA is a potent inhibitor of nitric oxide production. Here, we describe the development of a rapid and sensitive liquid chromatography tandem mass spectrometry method for simultaneous measurement of SDMA, ADMA and creatinine.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effectiveness of ultrafine particles (UFPs) like CoO and MnO as bactericidal agents, highlighting their potential to combat antibiotic resistance while being environmentally safe.
- Using advanced techniques, researchers analyzed how these UFPs affect bacterial cells' bioluminescence and morphology, revealing significant damage to cell walls and structures at effective concentrations.
- The research suggests safe dosage limits for using these UFPs in animal feed, while also acknowledging the need for further studies on their toxic effects on bacteria and other biological systems.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!