Dietary fat is an important source of nutrition. Here we identify eight mutations in SARA2 that are associated with three severe disorders of fat malabsorption. The Sar1 family of proteins initiates the intracellular transport of proteins in COPII (coat protein)-coated vesicles. Our data suggest that chylomicrons, which vastly exceed the size of typical COPII vesicles, are selectively recruited by the COPII machinery for transport through the secretory pathways of the cell.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/ng1145 | DOI Listing |
Publication Analysis
Top Keywords
copii vesicles
8
mutations sar1
4
sar1 gtpase
4
copii
4
gtpase copii
4
vesicles associated
4
associated lipid
4
lipid absorption
4
absorption disorders
4
disorders dietary
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!