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Pathophysiological Significance of α-Synuclein in Sympathetic Nerves: In Vivo Observations.
Neurology
February 2025
From the Autonomic Medicine Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD.
Background And Objectives: Lewy body diseases (LBDs) such as Parkinson disease (PD) feature increased deposition of α-synuclein (α-syn) in cutaneous sympathetic noradrenergic nerves. The pathophysiologic significance of sympathetic intraneuronal α-syn is unclear. We reviewed data about immunoreactive α-syn, tyrosine hydroxylase (TH, a marker of catecholaminergic fibers), and the sympathetic neurotransmitter norepinephrine (NE) in skin biopsies from control participants and patients with PD, the related LBD pure autonomic failure (PAF), the non-LBD synucleinopathy multiple system atrophy (MSA), or neurologic postacute sequelae of severe acute respiratory syndrome coronavirus 2 (neuro-PASC).
View Article and Find Full Text PDFThe Use of Sodium Chloride Powder Sachets May Not Increase the Risk of Microplastic Emissions in Nasal Irrigation Fluids: A Preliminary Study.
J Rhinol
November 2024
Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
Article Synopsis
- Microplastics are released during the preparation of homemade saline solutions, primarily from the tearing of powder packets and mixing with water, posing risks to humans and the environment.
- The study utilized polypropylene nasal irrigation bottles and compared microplastic content in samples with and without sodium chloride, revealing no significant difference in microplastic levels between the two groups.
- Identified polymers included polypropylene, polyethylene, and polyethylene terephthalate, with control samples containing more fibers, while the powder-added samples had a higher proportion of fragments.
Introduction: Lichen planus pigmentosus (LPP) is an uncommon variant of lichen planus, characterized by the insidious onset of dark brown to gray pigmented macules, mainly in sun-exposed areas and flexural folds. It is mainly reported in Indian, Latino, American, and Middle Eastern patients. This paper aims to document the clinicopathological characteristics of LPP.
View Article and Find Full Text PDFAn Outside-the-Box Approach for Treating a Rare Case of Urethrovaginal Fistula.
Cureus
November 2024
Urology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University) Pune, Pune, IND.
Urethrovaginal fistulas are rare complications often arising from urethrovaginal injuries commonly due to obstetrical trauma, urethral surgeries, pelvic fractures, or neoplastic treatments. Here, we present a unique case involving a 23-year-old female patient with a large urethrovaginal fistula and complete anterior vaginal wall sloughing following prolonged obstructed labor. Nine months post-cesarean, she reported urine leakage via the vagina upon catheter removal, which intensified in an erect posture.
View Article and Find Full Text PDFThe Effect of Intradermal Injection with Two Different Injection Techniques on Pain and Functional Status in Patients with Chronic Nonspecific Neck Pain.
Medeni Med J
December 2024
İstanbul Medeniyet University Faculty of Medicine, Department of Physical Medicine, Division of Rehabilitation, İstanbul, Türkiye.
Objective: This study aimed to compare the effectiveness of different mesotherapy techniques applied at various dermal depths on pain, functional status, and quality of life in patients with non-specific neck pain.
Methods: A total of 43 patients who received mesotherapy for non-specific neck pain were retrospectively analyzed. Patients treated with the point-by-point technique (n=21) and the napaj technique (n=22) were recorded.
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