Bioterrorism is an area of increasing public health concern. The intent of this article is to review the air cleansing technologies available to protect building occupants from the intentional release of bioterror agents into congregate spaces (such as offices, schools, auditoriums, and transportation centers), as well as through outside air intakes and by way of recirculation air ducts. Current available technologies include increased ventilation, filtration, and ultraviolet germicidal irradiation (UVGI) UVGI is a common tool in laboratories and health care facilities, but is not familiar to the public, or to some heating, ventilation, and air conditioning engineers. Interest in UVGI is increasing as concern about a possible malicious release of bioterror agents mounts. Recent applications of UVGI have focused on control of tuberculosis transmission, but a wide range of airborne respiratory pathogens are susceptible to deactivation by UVGI. In this article, the authors provide an overview of air disinfection technologies, and an in-depth analysis of UVGI-its history, applications, and effectiveness.
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http://dx.doi.org/10.1093/phr/118.2.99 | DOI Listing |
PLoS One
December 2024
Department of Health Promotion, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
During the COVID-19 pandemic, meatpacking workers were disproportionately affected by disease. Large outbreaks at meatpacking facilities resulted in loss of life and threatened the well-being of workers across the globe. Much work was done throughout the pandemic to understand and prevent these outbreaks.
View Article and Find Full Text PDFPhotochem Photobiol
December 2024
Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo, Japan.
The ocular safety of 222-nm far-ultraviolet-C (UV-C) irradiation, widely recognized for its germicidal properties, was evaluated in a clinical setting to assess its long-term health effects on the human eye. This prospective observational study involved a 36-month follow-up of physicians working in an ophthalmic examination room equipped with 222-nm UV-C lamps. Initially, a 12-month observation showed no signs of acute or chronic ocular damage.
View Article and Find Full Text PDFFood Microbiol
March 2025
Department of Food Science and Human Nutrition, University of Illinois Urbana-Champaign, Urbana, IL, 61801, United States; Center for Digital Agriculture, University of Illinois Urbana-Champaign, Urbana, IL, 61801, United States. Electronic address:
The safety of ready-to-eat (RTE) deli meats, especially those sliced in retail establishments, may be improved by light-based surface decontamination. Conventional 254 nm ultraviolet-C (UVC) systems have strong germicidal effects but pose human-health hazards that make them unsuitable for retail use. This study therefore explores the efficacy of microplasma-based 222 nm far-UVC lamps as a safer alternative for decontaminating liquid buffer, two common food-contact surfaces (polyethylene terephthalate and stainless steel), and RTE turkey breast.
View Article and Find Full Text PDFJ Hazard Mater
November 2024
School of Energy and Environment, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong; Department of Architecture and Civil Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong. Electronic address:
Ultraviolet germicidal irradiation (UVGI) technology can inhibit the environmental transmission of airborne pathogens, but the dose-response behavior of airborne human coronavirus and wavelength-specific inactivation mechanisms are not well understood. This study investigated three competitive UVC sources for their inactivation efficacy and mechanisms against human coronavirus OC43 (HCoV-OC43). Results showed the following order of inactivation efficacy: 222-nm KrCl excimer lamp > 263-nm UV-LEDs > 254-nm low-pressure mercury lamp.
View Article and Find Full Text PDFAntioxidants (Basel)
November 2024
Institute of Eye Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970473, Taiwan.
Far-ultraviolet C (far-UVC) light shows promise for pathogen control but its safety and efficacy for corneal disinfection remain unclear. In this study, safe far-UVC dosages were investigated for corneal disinfection and its germicidal performance and oxidative damage potential to 5% povidone-iodine (PVP-I) were compared. Rat corneas were exposed to varying 222 nm far-UVC doses (3-60 mJ/cm) and assessed for ocular damage, apoptosis, and oxidative stress to determine the safe dose of far-UVC.
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