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Stochasticity in dietary restriction-mediated lifespan outcomes in Drosophila.
Geroscience
January 2025
Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Dietary restriction (DR) is widely considered to be one of the most potent approaches to extend healthy lifespan across various species, yet it has become increasingly apparent that DR-mediated longevity is influenced by biological and non-biological factors. We propose that current priorities in the field should include understanding the relative contributions of these factors to elucidate the mechanisms underlying the beneficial effects of DR. Our work conducted in two laboratories represents an attempt to unify DR protocols in Drosophila and to investigate the stochastic effects of DR.
View Article and Find Full Text PDFTargets Selection for Precision Therapy of Relapsed/Refractory Multiple Myeloma: the Latest Advancements.
Curr Treat Options Oncol
January 2025
Tianjin Medical University General Hospital, 154 Anshan Road, Tianjin, 300052, Heping District, China.
According to the guidelines, the primary treatment for multiple myeloma is still based on drugs such as carfilzomib, lenalidomide, or daratumumab. However, patients with relapsed/refractory multiple myeloma (RRMM) may be insensitive or develop resistance to the above therapeutic medications. Thus, formulating standardized and rational treatment regimens for such patients remains an area for consideration.
View Article and Find Full Text PDFAdverse events and paramedic interventions during extended ground transport in a rural pharmaco-invasive STEMI program.
Emerg Med Australas
February 2025
Orange Health Service, Western NSW Local Health District, Dubbo, New South Wales, Australia.
Objective: Although guidelines recommend angiography and coronary intervention occur within 24 h of thrombolysis when percutaneous coronary intervention (PCI) is not available within 120 min, this target is difficult to achieve in rural and remote areas of New South Wales (NSW), Australia.
Methods: In this is secondary analysis we examine the impact of extending the existing 90-min road transport limit for patients in rural and remote areas of western NSW who have received initial treatment for ST-elevation myocardial infarction.
Results: The patient cohort consisted of 86 patients who were transported by road ambulance with transport times more than 90 min.
Knowledge and attitudes about dementia among nursing students in Vietnam: a cross-sectional study.
Psychogeriatrics
March 2025
Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
Background: Dementia is one of the most pressing health concerns among the ageing population, imposing significant health, financial and caregiving burdens on people with dementia (PWD), their families and caregivers. Building the capacity of nursing students is essential for effectively improving quality of life for affected people. This study aimed to assess nursing students' knowledge and attitudes toward dementia and its associated factors.
View Article and Find Full Text PDFBarriers and Enablers for Accessing Rehabilitation Services: Findings From the Rehabilitation Choices Study, Part 1-Healthcare Professionals' Perspectives.
Health Expect
June 2024
Centre for Rehab Innovations, University of Newcastle, Callaghan, New South Wales, Australia.
Introduction: Globally, there is an increasing demand for quality medical rehabilitation services. This is the first article of a two-part series showing the findings from the Rehabilitation Choices study in which the main aim was to understand the current landscape of decision-making, enablers and barriers to access appropriate rehabilitation services in the Australian setting. In Part 1, these insights were sought from a healthcare professionals' perspective.
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