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Long-term clinical outcome of a weekly 2-chlorodeoxyadenosine regimen in treatment-naïve patients with hairy cell leukemia.
Ann Hematol
January 2025
Department of Hematology, Seoul St. Mary's Hematology Hospital, College of Medicine, The Catholic University of Korea, Banpo-daero 222, Seocho-Gu, Seoul, South Korea.
Hairy cell leukemia (HCL) has a favorable clinical outcome with appropriate treatment; however, further research is needed on managing patients with relapsed or refractory disease and the risk of infection during prolonged periods. This study examined the long-term effects of 2-chlorodeoxyadenosine (2-CdA), particularly using a weekly infusion protocol, in treatment-naïve patients with HCL. This retrospective study evaluated the long-term follow-up data from 21 South Korean patients diagnosed with HCL.
View Article and Find Full Text PDFNon-V600E BRAF mutations and treatment for Hairy Cell Leukemia.
Blood
December 2024
National Cancer Institute, NIH, Bethesda, Maryland, United States.
We found 18 patients with immunophenotype consistent with classic hairy cell leukemia (HCL) and BRAF mutations other than just V600E. Twelve had 1 non-V600E BRAF mutation and 6 had V600E with 1 (n=5) or 2 (n=1) non-V600E BRAF co-mutations.
View Article and Find Full Text PDFUtility of Keystone Flap in Armory of Dermatosurgeons.
Indian J Dermatol
October 2024
Department of Burns and Plastic Surgery and Hypospadias and VVFs Clinic, Postgraduate Institute of Medical Sciences (PGIMS), University of Health Sciences, Rohtak (UHSR), Haryana, India.
Purpose And Background: To create awareness among dermatosurgeons about the versatility of keystone flaps in re-surfacing post-excisional small, medium and large skin defects.
Aims And Objectives: Single-staged tension-free re-surfacing of various sized skin defects using keystone flap and to have least donor site morbidity, primary healing and maximum functional outcome.
Material And Methods: This retrospective study was conducted, between October 2021 - January 2023 in Department of Plastic Surgery, PGIMS Rohtak, on 15 males and 1 female aged between 18 - 65 years.
Efficient hairy root induction system of Astragalus membranaceus and significant enhancement of astragalosides via overexpressing AmUGT15.
Plant Cell Rep
November 2024
Key Laboratory of Developmental Biology, Ministry of Education, Northeast Forestry University, Harbin, 150040, China.
Astragalus membranaceus hairy roots induced by direct injection of Rhizobium rhizogenes with AmUGT15 overexpressing genes into the stem explants demonstrate enhanced astragaloside biosynthesis Astragalus membranaceus is a widely used medicinal plant, which has important economic, ecological, medicinal, and ornamental values for accumulating various triterpene saponins named astragalosides in roots. Although the hairy root culture technique has been established in A. membranaceus, the molecular regulation of metabolic pathways for improving astragaloside contents was not reported.
View Article and Find Full Text PDFMetabolic engineering of hairy root cultures in for enhanced production of vanillin, 4-hydroxybenzoic acid, and vanillyl alcohol.
Front Bioeng Biotechnol
October 2024
CSIR-Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow, Uttar Pradesh, India.
The flavor of vanilla is a complex blend of compounds, with vanillin as the most prominent, along with vanillyl alcohol and 4-hydroxybenzoic acid. Natural vanillin extracted from vanilla beans is expensive, so researchers use heterologous synthesis to produce nature-identical vanillin in plant hosts. Consequently, alternative traditional farming and gathering methods are required to bridge the significant disparity between supply and demand.
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