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Bi-lineage B- and T-lymphoid Extramedullary Blast Crisis at an Initial Presentation of Chronic Myeloid Leukemia: A Case Report and Literature Review of Extramedullary Blast Crisis.
Cureus
November 2023
Department of Clinical Hematology, Ibn Sina Hospital, University Mohamed V of Medicine, Rabat, MAR.
Chronic myeloid leukemia (CML) with BCR-ABL1-positive cells is a myeloproliferative neoplasm (MPN) characterized by a chromosomal translocation t(9,22)(q34.1;q11.2), which results in the formation of a Philadelphia (Ph) chromosome containing the BCR-ABL1 fusion gene.
View Article and Find Full Text PDFAcute myelomonocytic leukemia and T-lymphoblastic lymphoma as simultaneous bilineage hematologic malignancy treated with decitabine: A case report.
World J Clin Cases
July 2023
Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju 54907, South Korea.
Background: Simultaneous bilineage hematologic malignancies are rare; however, several cases of acute myeloid leukemia (AML) and T-lymphoblastic lymphoma (T-LBL) co-occurrence have been reported. A standard treatment for simultaneous AML and T-LBL has not yet been established, and its prognosis is very poor. Further studies to develop standard treatments are required to increase patient survival rates.
View Article and Find Full Text PDFBackground: As a rare heterogeneous kind of acute leukemia, mixed-phenotype acute leukemia (MPAL) co-expresses more than one cell lineage and could contain bilineal, biphenotypic, or a combination. MPAL is classified as T/myeloid, B/myeloid, B/T-lymphoid, and trilineage B/T/myeloid.
Method: Here, we report a rare case of T/Myeloid bilineage mixed-phenotype acute leukemia with basophilia.
Coexistence of Non-Hodgkin's Lymphoma and Acute Myeloid Leukemia at Initial Diagnosis: A Case Report.
Curr Med Imaging
June 2023
Department of Nuclear Medicine, Jiangxi Cancer Hospital, Nanchang, Jiangxi, China.
Unlabelled: Non-Hodgkin's lymphoma and acute myeloid leukemia are both hematological malignancies that rarely coexist at the time of initial diagnosis. We present a case of non-Hodgkin lymphoma and acute myeloid leukemia diagnosed on the first admission.
Background: Lymphoma and leukemia, both malignant hematological cancers, are primarily different diseases, with a majority of cases originating independently.
Hypocupremia can result in a bi-lineage deficiency of leukocytes and erythrocytes. Although commonly seen from gastrointestinal malabsorption, hypocupremia can be further exacerbated with excessive zinc intake causing increased fecal copper excretion. Dietary supplementation is prevalent in the outpatient setting and must be considered as a possible source of hematologic pathologies.
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