A study of the relationship between ameloblastoma and human papilloma virus.

J Oral Maxillofac Surg

Department of Oral and Maxillofacial Surgery, Taleghani Medical Health Sciences Center, Shahid Beheshti Medical Sciences University, Tehran, Iran.

Published: April 2003

Purpose: The purpose of this study was to determine the relation of ameloblastoma with one of its probable etiologic factors, human papilloma virus (HPV).

Materials And Methods: This study was carried out in a retrospective, observational, and blind manner with information forms using an exact polymerize chain reaction. Fifty paraffinated blocks of ameloblastoma tumor were compared with 50 impacted third molar follicles.

Results: The results indicate that statistically the incidence of HPV positivity in the case group is significantly higher than that in the control group (P <.025). Furthermore, in determination of trace HPV type in HPV-positive samples, the incidence of type 6 HPV in the case group is significantly higher than that in the control group (P <.005). None of types 8, 11, 16, 18, 31, and 33 were observed.

Conclusion: The results of this research conclude that HPV could be regarded as a possible etiologic factor of ameloblastoma.

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Source
http://dx.doi.org/10.1053/joms.2003.50011DOI Listing

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