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The Sr1 gene that controls diversity of the anti-inulin antibody response maps to mouse chromosome 14. | LitMetric

The Sr1 gene that controls diversity of the anti-inulin antibody response maps to mouse chromosome 14.

Immunogenetics

Division of Monoclonal Antibodies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.

Published: May 2003

AI Article Synopsis

  • * BALB/c mice have a consistent antibody response while (BALB/cxC57BL/6)F1 mice exhibit a more varied response, indicating genetic differences affect immunity.
  • * Genetic analysis places the Sr1 gene on chromosome 14, suggesting it is linked to T-cell receptor genes which may play a role in enhancing the diversity of the immune response.

Article Abstract

Previous studies demonstrated that the diversity of the antibody response of mice to the inulin (In) determinant of bacterial levan is regulated by the gene Spectrotype Regulation 1 ( Sr1). BALB/c mice produce a monoclonal anti-In response as shown by isoelectric focusing analysis. In contrast, the anti-In antibody response of (BALB/cxC57BL/6)F1 mice is significantly more heterogeneous. We performed a backcross and a genome-wide scan with microsatellite markers and found that Sr1 is tightly linked to D14Mit121 on chromosome (Chr) 14. This location for Sr1 was supported by analysis of CXB Recombinant Inbred strains. We further confirmed this by finding that the Chr 14 congenic mouse strain B6.C-H8 lacks the C57BL/6 allele of the Sr1 gene, indicating that Sr1 is located in the segment of Chr 14 replaced with BALB/c donor DNA. These data place Sr1 near to or coincident with the Tcra/Tcrd T-cell receptor gene complex and suggest a role for T cells in diversifying the anti-In response.

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Source
http://dx.doi.org/10.1007/s00251-003-0555-zDOI Listing

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