AI Article Synopsis
- 13 cases of osteomyelitis linked to Aspergillus nidulans in patients with chronic granulomatous disease (CGD) were previously noted, all with poor outcomes and associated pulmonary infections.
- A rare case of femoral osteomyelitis due to A. nidulans is reported in a 16-year-old male with CGD who did not have lung infection.
- The patient responded well to treatment that included liposomal amphotericin B, granulocyte colony-stimulating factor, extensive surgical debridement, and prolonged itraconazole therapy.
Article Abstract
13 cases of osteomyelitis caused by Aspergillus nidulans have been previously reported in patients with chronic granulomatous disease (CGD). All of them have been associated with simultaneous pulmonary infection and have had an extremely poor outcome. We report an unusual case of femoral osteomyelitis due to A. nidulans in a 16-year-old male with CGD, without pulmonary involvement. Treatment with liposomal amphotericin B and granulocyte colony-stimulating factor as well as extensive surgical debridement followed by prolonged treatment with itraconazole resulted in an excellent clinical response.
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