AI Article Synopsis
- The study explored the antinociceptive effects of bee venom (BV) when injected into a specific acupoint (Zusanli or ST36) in rats.
- BV pretreatment significantly reduced pain behavior, measured by paw-licking time during a formalin test, indicating pain relief.
- Additionally, BV reduced spinal cord Fos expression, further supporting its potential as a pain management treatment through acupuncture.
Article Abstract
In two previous reports, we have demonstrated that injection of bee venom (BV) into an acupoint produces a significant antinociceptive and anti-inflammatory effect in both a mouse model of visceral nociception and a rat model of chronic arthritis. The present study was designed to evaluate the potential antinociceptive effect of BV pretreatment on formalin-induced pain behavior and it associated spinal cord Fos expression in rats. Adult Sprague-Dawley rats were injected with BV directly into the Zusanli (ST36) acupoint or into an arbitrary non-acupoint located on the back. BV pretreatment into the Zusanli acupoint significantly decreased paw-licking time in the late phase of the formalin test. In contrast, BV injected into a non-acupoint in the back region did not suppress the paw-licking time. In addition, BV pretreatment into the Zusanli acupoint markedly inhibited spinal cord Fos expression induced by formalin injection. These findings indicate that BV pretreatment into the Zusanli acupoint has an antinociceptive effect on formalin-induced pain behavior.
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| http://dx.doi.org/10.1292/jvms.65.349 | DOI Listing |
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