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Identification of genes associated with the high-temperature fermentation trait in the Saccharomyces cerevisiae natural isolate BCC39850.
Arch Microbiol
September 2024
The Laboratory of Systems and Synthetic Biology, Wageningen University and Research, Stippeneng 4, Wageningen, 6708 WE, the Netherlands.
The fermentative model yeast Saccharomyces cerevisiae has been extensively used to study the genetic basis of stress response and homeostasis. In this study, we performed quantitative trait loci (QTL) analysis of the high-temperature fermentation trait of the progeny from the mating of the S. cerevisiae natural isolate BCC39850 (haploid#17) and the laboratory strain CEN.
View Article and Find Full Text PDFTo heat or not to heat: the impact of temperature on the aggregation state of amphotericin B in drug delivery systems.
Nanomedicine (Lond)
October 2024
Department of Pharmacy, Faculty of Biological and Health Sciences, Federal University of the Jequitinhonha and Mucuri Valleys, Diamantina, Minas Gerais, Brazil.
Fabrication data of two light-responsive systems to release an antileishmanial drug activated by infrared photothermal heating.
Data Brief
April 2022
Departamento de Química Inorgânica, Universidade Federal Fluminense, Campus do Valonguinho, Niterói-RJ, 24020-150, Brazil.
The data provided in this study are related to the fabrication of two light-responsive systems based on reduced graphene oxide (rGO) functionalized with the polymers Pluronic P123 (P123), rGO-P123, and polyethyleneimine (PEI), rGO-PEI, and loaded with amphotericin B (AmB), an antileishmanial drug. Here are described the experimental design to obtain the systems and characterization methods, such as Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR), Raman Spectroscopy, Powder X-Ray Diffraction, Transmission Electron Microscopy, Scanning Electron Microscopy and Thermogravimetric Analyses. Also, AmB spectroscopy studies are described.
View Article and Find Full Text PDFSuper aggregated amphotericin B with a thermoreversible in situ gelling ophthalmic system for amoebic keratitis treatment.
Acta Trop
December 2021
Universidade Federal de Santa Catarina (UFSC), Centro de Ciências da Saúde, Departamento de Análises Clínicas, Laboratório de Estudos de Protozoários Emergentes e Oportunistas. CEP: 88040-970, Florianópolis, Santa Catarina, Brazil.. Electronic address:
Acanthamoeba spp. are the causative agents of a sight-threatening infection of the cornea known as Acanthamoeba keratitis (AK). Amphotericin B - deoxycholate (AB) is used in the treatment of infectious keratitis, however, its topical administration has side effects as blepharitis, iritis, and painful instillation.
View Article and Find Full Text PDFMagnetic hyperthermia adjunctive therapy for fungi: studies against .
Int J Hyperthermia
December 2019
a Centre for Biosystems Science and Engineering , Indian Institute of Science, Bangalore , India.
The poor penetration of anti-fungal agents into the cornea through the intact epithelium layer makes it difficult to treat acute fungal corneal infections. Herein, we developed Amphotret (amphotericin B) antifungal drug contained polycaprolactone-FeO (PCL-FO) magnetic nanofibers (MNFs) using the electrospinning technique. These MNFs generate heat in the presence of AC magnetic field (AMF) and release drug upon heating.
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