AI Article Synopsis
- Successful gene therapy relies on effective gene transfer vectors, both viral and non-viral, with cationic lipids being a notable non-viral option due to their pharmaceutical-like properties and minimal immunogenicity.
- Despite their advantages, cationic lipids face challenges such as toxicity and low transfection efficiency that hinder their use in clinical settings.
- Recent research has focused on enhancing cationic lipids' effectiveness through structural optimization of DNA/liposome complexes and innovative design strategies, including the use of disulfide cationic lipids for plasmid DNA delivery.
Article Abstract
Successful gene therapy depends on efficient gene transfer vectors. Viral vectors and non-viral vectors have been investigated extensively. Cationic lipids are non-viral vectors, which resemble traditional pharmaceuticals, display little immunogenicity, and have no potential for viral infection. However, toxicity and low transfection efficiency are two barriers limiting the clinical applications of cationic lipids. Over the last decade, hundreds of cationic lipids have been synthesized to address these problems. In this brief review, we summarized recent research results concerning the structures of DNA/liposomes complexes, some important strategies used to design different classes of cationic lipids, and use of disulfide cationic lipids in plasmid DNA delivery.
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| http://dx.doi.org/10.2174/0929867033457412 | DOI Listing |
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