AI Article Synopsis
- Representational difference analysis (RDA) identified a new amplicon at chromosomal region 8q24.3 in human breast cancer samples.
- KCNK9, the only gene overexpressed in this amplified region, shows a significant increase in expression, ranging from 5-fold to over 100-fold in a large percentage of breast tumors.
- Overexpression of KCNK9 in cell lines contributes to tumor growth and resistance to low oxygen and serum levels, indicating its key role in the progression of breast cancer.
Article Abstract
Representational difference analysis (RDA) of human breast cancer was used to discover a novel amplicon located at chromosomal region 8q24.3. We examined a series of breast cancer samples harboring amplification of this region and determined that KCNK9 is the sole overexpressed gene within the amplification epicenter. KCNK9 encodes a potassium channel that is amplified from 3-fold to 10-fold in 10% of breast tumors and overexpressed from 5-fold to over 100-fold in 44% of breast tumors. Overexpression of KCNK9 in cell lines promotes tumor formation and confers resistance to both hypoxia and serum deprivation, suggesting that its amplification and overexpression plays a physiologically important role in human breast cancer.
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| http://dx.doi.org/10.1016/s1535-6108(03)00054-0 | DOI Listing |
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