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Performance of deep learning model and radiomics model for preoperative prediction of spread through air spaces in the surgically resected lung adenocarcinoma: a two-center comparative study.
Transl Lung Cancer Res
December 2024
Department of Radiology, Second Affiliated Hospital of Naval Medical University, Shanghai, China.
Background: Spread through air spaces (STAS) in lung adenocarcinoma (LUAD) is a distinct pattern of intrapulmonary metastasis where tumor cells disseminate within the pulmonary parenchyma beyond the primary tumor margins. This phenomenon was officially included in the World Health Organization (WHO)'s classification of lung tumors in 2015. STAS is characterized by the spread of tumor cells in three forms: single cells, micropapillary clusters, and solid nests.
View Article and Find Full Text PDFBackground: (), which possesses various biological effects, has been widely used as traditional medicine and functional food in Asian countries, especially China. In consideration of its various biological effects on human healthcare, . was usually used in combination with other drugs.
View Article and Find Full Text PDFHealthcare leadership for a climate resilient future.
BMJ
October 2024
The Nature Conservancy, Arlington VA, USA.
DCRM 2.0: Multispecialty practice recommendations for the management of diabetes, cardiorenal, and metabolic diseases.
Metabolism
October 2024
Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Article Synopsis
- The spectrum of cardiorenal and metabolic diseases includes various disorders like obesity, type 2 diabetes, chronic kidney disease, and heart failure, often co-existing in the same patient due to shared physiological pathways.
- Recent trials have shown that treatments can benefit multiple conditions simultaneously, highlighting a need for updated clinical guidance.
- An international task force of specialists has created the DCRM 2.0 Practice Recommendations, which consist of 22 graphics to help clinicians manage these complex conditions effectively, aiming to enhance patient health and outcomes.
Preparation and partial pharmacodynamic studies of luliconazole ethosomes.
Clin Exp Pharmacol Physiol
May 2022
Department of Dermatology, the Frist Medical Centre, Chinese PLA General Hospital, Beijing, China.
As a drug carrier, ethosome is found to be efficient in delivering drug to the deep skin layers through stratum corneum, and the purpose of this paper is to develop luridazole ethosomes acting as an optimal choice for transdermal antifungal drugs. The luliconazole ethosomes were prepared by thin-film hydration, and evaluated for morphology, size, entrapment efficiency (EE), stability and deformability. In vitro, the transdermal experiment was performed on excised rat skin by Franz diffusion cell, and minimum inhibitory concentration (MIC) was applied to determine antifungal activity.
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