Combination of drugs or polypharmacy is a therapeutic procedure and this can be needed in diabetes also. To consider the basis of polypharmacy, certain knowledges regarding likely mechanism operating in diabetic patient are to be known. Drugs available in polypharmacy are well elaborated in this article. The drugs can be categorised in three headings: Obese type 2 diabetes mellitus, non-obese or standard weight diabetes and low body weight subjects. Severity of hyperglycaemia is another factor to be looked into while treating type 2 diabetic patients. Besides, certain other situations are narrated where the combination therapy can be helpful.
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