The changes of the thymic cytologia under the action of genital hormones were studied in giunea pigs. The conclusion of the experiments was: the oestrogens are the only hormones to induce a fast and complete involution of the thymic tissue with appearance of Foa-Kurloff cells'. The cell seems to have all the necessary characters to be the morphologic substratum of an eventual cytocrine secretion of the thymus.
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