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Background: Training in complex high-risk indicated percutaneous coronary intervention (CHIP-PCI) has frequently been reserved for established operators (consultants/attending) with trainees (fellows-in-training or FIT) being often discouraged from carrying out such procedures as a primary operator due to their high-risk nature. Whether the outcomes of these cases differ if the primary operator is a supervised FIT compared with a consultant is unknown.
Methods: Using multicentre PCI data from three cardiac centres in South Wales, UK (2018-2022), we identified 2295 CHIP-PCI cases with a UK-BCIS CHIP Score of 3 or more.
Generative design of crystal structures by point cloud representations and diffusion model.
iScience
January 2025
School of Physics and Electronic Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.
Efficiently generating energetically stable crystal structures has long been a challenge in material design, primarily due to the immense arrangement of atoms in a crystal lattice. To facilitate the discovery of stable materials, we present a framework for the generation of synthesizable materials leveraging a point cloud representation to encode intricate structural information. At the heart of this framework lies the introduction of a diffusion model as its foundational pillar.
View Article and Find Full Text PDFImpact of sodium-glucose cotransporter-2 inhibitors on pulmonary vascular cell function and arterial remodeling.
World J Cardiol
January 2025
Chinese Academy Medical Sciences, Fuwai Yunnan Hospital, Kunming 650000, Yunnan Province, China.
Sodium-glucose cotransporter-2 (SGLT-2) inhibitors represent a cutting-edge class of oral antidiabetic therapeutics that operate through selective inhibition of glucose reabsorption in proximal renal tubules, consequently augmenting urinary glucose excretion and attenuating blood glucose levels. Extensive clinical investigations have demonstrated their profound cardiovascular efficacy. Parallel basic science research has elucidated the mechanistic pathways through which diverse SGLT-2 inhibitors beneficially modulate pulmonary vascular cells and arterial remodeling.
View Article and Find Full Text PDFCCI: A Consensus Clustering-Based Imputation Method for Addressing Dropout Events in scRNA-Seq Data.
Bioengineering (Basel)
January 2025
Division of Biostatistics, Data Science Institute, Medical College of Wisconsin (MCW), Milwaukee, WI 53226, USA.
Single-cell RNA sequencing (scRNA-seq) is a cutting-edge technique in molecular biology and genomics, revealing the cellular heterogeneity. However, scRNA-seq data often suffer from dropout events, meaning that certain genes exhibit very low or even zero expression levels due to technical limitations. Existing imputation methods for dropout events lack comprehensive evaluations in downstream analyses and do not demonstrate robustness across various scenarios.
View Article and Find Full Text PDFIntegrating microfluidics, hydrogels, and 3D bioprinting for personalized vessel-on-a-chip platforms.
Biomater Sci
January 2025
School of Biomedical Engineering, The University of Sydney, Darlington, NSW 2008, Australia.
Thrombosis, a major cause of morbidity and mortality worldwide, presents a complex challenge in cardiovascular medicine due to the intricacy of clotting mechanisms in living organisms. Traditional research approaches, including clinical studies and animal models, often yield conflicting results due to the inability to control variables in these complex systems, highlighting the need for more precise investigative tools. This review explores the evolution of thrombosis models, from conventional polydimethylsiloxane (PDMS)-based microfluidic devices to advanced hydrogel-based systems and cutting-edge 3D bioprinted vascular constructs.
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