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Idiopathic hypoparathyroidism presenting as fatigue.
BMJ Case Rep
December 2024
Ophthalmology, LLH Hospital, Abu Dhabi, Abu Dhabi, UAE.
Fatigue is a common symptom encountered in clinical practice, often posing a diagnostic challenge due to its myriad underlying causes. A comprehensive clinical history can serve as a valuable guide in such diagnostic dilemmas. A man in his 30s presented with a history of intermittent fatigue.
View Article and Find Full Text PDFEfficacy of dietary supplementation with 1α-hydroxycholecalciferol on performance, eggshell quality, serum metabolites, jejunal morphology and bone characteristics of laying hens at the late stage of production.
Poult Sci
January 2025
Department of Animal Science, College of Agriculture and Natural Resources, Razi University, Kermanshah, Iran.
The present study evaluated the effects of 1α-hydroxycholecalciferol (1αOHD) supplementation on performance, egg quality, gut morphology, serum metabolites, and bone characteristics of Lohman LSL-Lite laying hens. A total of 180 birds (110 weeks of age) were allocated according to a completely randomized design with five treatments. Each treatment had six replicates containing six hens each.
View Article and Find Full Text PDFParathyroid hormone-based algorithm reduces complications after total thyroidectomy.
Surgery
February 2025
Department of General and Endocrine Surgery, Pitié Salpêtrière Hospital, APHP, Sorbonne University, Paris, France; Groupe de Recherche Clinique No. 16 Thyroid Tumors, Sorbonne University, Paris, France.
Article Synopsis
- The study analyzed patients from 2017 to 2022, comparing postoperative serum calcium levels and PTH levels taken shortly after the surgery to create a management algorithm involving calcium and alfacalcidol for those with low intraoperative PTH levels.
- Results showed that using intraoperative PTH levels improved prediction of symptomatic hypocalcemia significantly, identifying 90% of cases, while only 58% could be predicted using postoperative serum calcium levels alone.
Alfacalcidol-Induced Kidney Injury in Patients with Severe Motor and Intellectual Disabilities.
J Nutr Sci Vitaminol (Tokyo)
October 2024
Department of Rehabilitation, Ichinomiya Medical Treatment & Habilitation Center.
Patients with severe motor and intellectual disabilities (SMID) often experience insufficient physical activity, leading to osteoporosis. The active form of vitamin D is commonly prescribed for the prevention or treatment of osteoporosis. We observed four cases of kidney injury believed to be associated with the administration of 1α-OH vitamin D (alfacalcidol) preparations.
View Article and Find Full Text PDFExploring the material basis and molecular targets of Changma Xifeng tablet in treating Tourette syndrome: an integrative approach of network pharmacology and miRNA analysis.
Metab Brain Dis
December 2024
Department of Neurology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
This study was to investigate the mechanism of Changma Xifeng tablet, a traditional Chinese medicine in the treatment of Tourette syndrome. Network pharmacology was utilized to pinpoint blood-entering constituents of Changma Xifeng and explore their potential targets. Additionally, differential microRNA expression analysis was conducted to predict Tourette syndrome-associated targets, complemented by molecular docking and dynamics simulations to support the interactions of the active compounds with these targets.
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