One of the irresistible allures of freshly fallen snow is the urge to flop onto the ground and slide downhill. Generations of families have been coming together to go sledding for centuries. Unfortunately, this perceived innocuous activity has predictable injury patterns, many of which are preventable with minimal effort or expense. Catastrophic injuries, not infrequently involving younger children, also seem to be preventable with education of the parents and the general public. The current authors reviewed the available literature on sledding injuries and summarized the findings on injury patterns and the recommendations on injury prevention. Proposals for injury prevention and public education, several of which have been designed by national interest groups, are included.
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http://dx.doi.org/10.1097/01.blo.0000057786.10364.07 | DOI Listing |
Alzheimers Dement
December 2024
NYU Grossman School of Medicine, New York, NY, USA; NYU, New York City, NY, USA.
Background: Astrocytes, a major glial cell in the central nervous system (CNS), can become reactive in response to inflammation or injury, and release toxic factors that kill specific subtypes of neurons. Over the past several decades, many groups report that reactive astrocytes are present in the brains of patients with Alzheimer's disease, as well as several other neurodegenerative diseases. In addition, reactive astrocyte sub-types most associated with these diseases are now reported to be present during CNS cancers of several types.
View Article and Find Full Text PDFBackground: Neuroinflammation is a critical factor of Alzheimer's Disease (AD). Dysregulation of complement leads to excessive inflammation, direct damage to self-cells and propagation of injury. This is likely of particular relevance in the brain where inflammation is poorly tolerated and brain cells are vulnerable to direct damage by complement.
View Article and Find Full Text PDFBackground: Microglial activation is one of the neuropathological hallmarks of Alzheimer's disease (AD). Evidence suggest that chronic activation of microglia cause neuroinflammation and neuronal injuries, contributing to cognitive impairment. Therefore, modulation of microglial pathway like CSF-1R represents an attractive therapeutic strategy.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Hospital Alemão Oswaldo Cruz, São Paulo, São Paulo, Brazil.
Background: People with dementia (PWD) have several unmet needs during the syndrome progression. More unmet needs are related to worse outcomes, such as hospitalizations, injuries, and death. The caregiving burden has been related to more PWD unmet needs.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Ontario Shores Centre for Mental Health Sciences, Whitby, ON, Canada.
Background: Neuropsychiatric symptoms (NPS) of dementia are a heterogenous group of non-cognitive symptoms and behaviors that occur in up to 90% of individuals with the condition. Characterizing NPS is a major issue and current methods are unreliable as they rely on subjective observations. Automatic identification of behaviors using central and peripheral physiological markers may be helpful to detect behaviors, allow for early intervention, and prevent critical incidents in patients with dementia.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!