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Background: Risk-versus-benefit optimization required a quantitative comparison of the two. The latter, directly related to effective diagnosis, can be associated to clinical risk. While many strategies have been developed to ascertain radiation risk, there has been a paucity of studies assessing clinical risk, thus limiting the optimization reach to achieve a minimum total risk to patients undergoing imaging examinations.

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Article Synopsis
  • VIPomas are rare tumors that cause life-threatening hormonal issues by secreting vasoactive intestinal peptide (VIP), and plasma VIP can be measured to confirm diagnosis, although interference in tests can occur.
  • Researchers developed three methods to detect potential interference in VIP radioimmunoassay (RIA) tests and studied both patients suspected of false positive VIP results and those with confirmed VIPomas.
  • Their results showed that all false positive patients had interference in the tests, whereas no such issues were found in confirmed VIPoma patients, indicating the importance of using their developed techniques when test results don't match clinical symptoms.
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Objective: To collect voided urine from dogs with clinical signs of lower UTI and determine the diagnostic performance of a commercially available rapid immunoassay (RIA) immediately after urine collection and after refrigeration at 4 and 24 hours.

Animals: 40 client-owned dogs.

Methods: Aerobic urine culture was performed on urine collected by cystocentesis.

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Optimization of the cut-offs in acetylcholine receptor antibodies and diagnostic performance in myasthenia gravis patients.

Clin Chim Acta

August 2022

Department of Neurology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. Electronic address:

Objective: This study aims to establish an optimization procedure to define the cut-offs of quantitative assays for acetylcholine receptor antibody (AChRAb), evaluate their diagnostic performance in myasthenia gravis (MG), and explore the association with clinical features.

Methods: Samples from a representative cohort of 77 MG patients, 80 healthy controls (HC) and 80 other autoimmune diseases (OAD) patients were tested using competitive inhibition ELISA and RIA. Raw values (OD and cpm) and processed values (inhibition rate, binding rate and concentration) were used to define the cut-offs with statistical methods, a rough method, and receiver operating characteristic (ROC) curve.

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A feasibility study investigating the utility of a point-of-care rapid immunoassay for detecting septic peritoneal effusion in dogs.

J Vet Emerg Crit Care (San Antonio)

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Critical Care Department, BluePearl Veterinary Partners, Queens, New York, USA.

Objective: To determine the sensitivity (SN), specificity (SP), positive predictive value (PPV), negative predictive value (NPV), and accuracy of a point-of-care urine bacterial rapid immunoassay (RIA) for a diagnosis of septic peritonitis, compared to more traditional diagnostic tools, such as cytology and bacterial culture.

Design: Prospective, cross-sectional feasibility study conducted from October 2016 to June 2017.

Setting: Four locations within a private practice referral hospital.

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