Nuclear hormone receptor assays for drug discovery. | LitMetric

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Nuclear hormone receptor assays for drug discovery. | LitMetric

Nuclear hormone receptor assays for drug discovery.

Jon Rosen Keith Marschke Deepa Rungta

Curr Opin Drug Discov Devel

Department of Molecular & Cell Biology, Ligand Pharmaceuticals Inc, 10275 Science Center Drive, San Diego, CA 92121, USA.

Published: March 2003

Nuclear receptors (NRs) are a superfamily of ligand-dependent transcription factors that control diverse aspects of growth, development and homeostasis, making them exciting and important targets for drug discovery. In this review, some of the recent advances in our understanding of NRs, and their application to the discovery of new ligands, will be discussed.

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