Immune functions encoded by the natural killer gene complex.

Nat Rev Immunol

Howard Hughes Medical Institute, Rheumatology Division, Department of Medicine, Barnes-Jewish Hospital and Washington University School of Medicine, Box 8045, 660 South Euclid Avenue, St Louis, Missouri 63110, USA.

Published: April 2003

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Article Abstract

There has been marked progress in our understanding of the role of natural killer (NK) cells in immune responses, mainly due to the identification of NK-cell receptors and their ligands. The genes encoding many NK-cell receptors are located in the NK-gene complex (NKC). Here, we review the properties of NKC-encoded receptors, and provide a genomic and conceptual framework for an insight into NK-cell function and biology.

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http://dx.doi.org/10.1038/nri1055DOI Listing

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