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iPREDICT: proof-of-concept study to develop a predictive model of changes in asthma control.
Ther Adv Respir Dis
July 2024
AstraZeneca, Gaithersburg, MD, USA.
Background: The individualized PREdiction of DIsease Control using digital sensor Technology (iPREDICT) program was developed for asthma management using digital technology. Devices were integrated into daily lives of patients to establish a predictive model of asthma control by measuring changes from baseline health status with minimal device burden.
Objectives: To establish baseline disease characteristics of the study participants, detect changes from baseline associated with asthma events, and evaluate algorithms capable of identifying triggers and predicting asthma control changes from baseline data.
iPREDICT: Characterization of Asthma Triggers and Selection of Digital Technology to Predict Changes in Disease Control.
J Asthma Allergy
July 2024
Content Strategy & Experience Design, Digital Global Commercial, AstraZeneca, Gaithersburg, MD, USA.
Purpose: The iPREDICT program aimed to develop an integrated digital health solution capable of continuous data streaming, predicting changes in asthma control, and enabling early intervention.
Patients And Methods: As part of the iPREDICT program, asthma triggers were characterized by surveying 221 patients (aged ≥18 years) with self-reported asthma for a risk-benefit analysis of parameters predictive of changes in disease control. Seventeen healthy volunteers (age 25-65 years) tested 13 devices to measure these parameters and assessed their usability attributes.
Assessment of Illness Severity in Adults Hospitalized With Acute Respiratory Tract Infection due to Influenza, Respiratory Syncytial Virus, or Human Metapneumovirus.
Influenza Other Respir Viruses
May 2024
Janssen Global Medical Affairs Infectious Diseases & Vaccines, Beerse, Belgium.
Background: Influenza, respiratory syncytial virus (RSV), and human metapneumovirus (hMPV) are common respiratory viruses causing similar symptoms. Optimal tools to assess illness severity for these viruses have not been defined. Using the Hospitalized Acute Respiratory Tract Infection (HARTI) study data, we report symptom severity by clinician-rated clinical severity scores (CSS) in adults with influenza, RSV, or hMPV and correlations between CSS and patient-reported outcomes (PROs).
View Article and Find Full Text PDFBlepharoclonus in Parkinsonism.
Neurol Clin Pract
February 2024
Neurology, University of Miami Miller School of Medicine, FL.
Background And Objectives: In clinical practice, we have observed that patients with Parkinson disease (PD) often have blepharoclonus, but its prevalence is not well described in the literature. Understanding the relative frequencies of blepharoclonus in PD and atypical parkinsonian syndromes may shed light on the diagnostic utility of this clinical sign. We aimed to assess (1) the frequency of blepharoclonus in patients with PD in a single-center cohort; (2) the association of blepharoclonus with disease stage, tremor severity, and non-motor symptoms; and (3) the frequency of blepharoclonus in synucleinopathy vs non-synucleinopathy-associated parkinsonism.
View Article and Find Full Text PDFLipid-Lowering Therapy in the Elderly: Are Current Guidelines a Sign of Ageism in Medical Care?
J Am Coll Cardiol
April 2023
Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA. Electronic address: https://twitter.com/LaylaAbushamat.
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